Internal Medicine Department, General Health Check-up Unit, Clínica Universidad de Navarra. Avenida Pío XII, 36, 31008 Pamplona, Navarra, Spain; COVID-19 department, Clínica Universidad de Navarra, Avenida Pío XII, 36, 31008 Pamplona, Navarra, Spain;.
COVID-19 department, Clínica Universidad de Navarra, Avenida Pío XII, 36, 31008 Pamplona, Navarra, Spain;; Pulmonary Medicine Department, Clínica Universidad de Navarra, Avenida Pío XII, 36, 31008 Pamplona, Navarra, Spain.
Eur J Intern Med. 2021 Sep;91:3-9. doi: 10.1016/j.ejim.2021.03.031. Epub 2021 Apr 2.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance.
严重急性呼吸综合征冠状病毒 2（SARS-CoV2）疾病（COVID-19）是一种新的威胁，特别是在肥胖个体中会降低预期寿命。尽管这种关联具有临床相关性，但潜在机制尚未完全阐明。SARS-CoV2 通过血管紧张素转换酶 2 受体进入宿主细胞，该受体也在脂肪组织中表达。此外，脂肪组织也是许多促炎介质和脂肪因子的来源，由于慢性低度炎症的预先条件，这些介质和脂肪因子可能会增强 COVID-19 的特征性细胞因子风暴。此外，肥胖相关的胸机械限制也可能对 COVID-19 肥胖患者的预后产生负面影响。本综述总结了目前关于肥胖相关情况触发 COVID-19 严重程度增加风险的知识体系，以及它们的临床相关性。
