Mansourian Arash, Agha-Hosseini Farzaneh, Kazemi Hamed Hossein, Mortazavi Nazanin, Moosavi Mahdieh-Sadat, Beytollahi Jalil, Mirzaii-Dizgah Iraj
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Department of Oral Medicine, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Dent Res J (Isfahan). 2017 Mar-Apr;14(2):104-110.
Total antioxidant capacity (TAC) and malondialdehyde (MDA) levels have not been reported in oral lichen planus (OLP) patients treated with a topical corticosteroid. This study evaluates TAC and MDA levels in unstimulated saliva of OLP patients. Such measurements may need to be supported by clinical observation.
Twenty patients with OLP participated in a study conducted at the Department of Oral Medicine, Tehran University of Medical Sciences. Salivary TAC and MDA were determined by biochemical analyses before and after 5-week triamcinolone acetonide (0.2%) mouthrinse treatment. Subjective symptoms as well as lesion status pre- and post-treatment were measured using visual analog scale (VAS) and clinical scoring system, respectively. Wilcoxon signed rank test was used for the evaluation of MDA and TAC parameters, VASs, and rates of clinical scores. Spearman's rank correlation was used to determine the relationship between different variables.
A statistically significant increase in salivary TAC was found after treatment. There was no significant difference in the reduction of salivary MDA levels in OLP patients after treatment.
Posttreatment analyses revealed a significant degree of recovery and pain relief of OLP lesions. Hence, triamcinolon mouthrinse by reducing oxidative stress is an appropriate treatment in OLP patients.
尚未有关于接受局部皮质类固醇治疗的口腔扁平苔藓（OLP）患者的总抗氧化能力（TAC）和丙二醛（MDA）水平的报道。本研究评估OLP患者非刺激性唾液中的TAC和MDA水平。此类测量可能需要临床观察的支持。
20名OLP患者参与了在德黑兰医科大学口腔医学系进行的一项研究。在使用曲安奈德（0.2%）漱口水治疗5周前后，通过生化分析测定唾液TAC和MDA。分别使用视觉模拟量表（VAS）和临床评分系统测量治疗前和治疗后的主观症状以及病变状态。采用Wilcoxon符号秩检验评估MDA和TAC参数、VAS以及临床评分率。使用Spearman秩相关分析来确定不同变量之间的关系。
治疗后唾液TAC有统计学意义的升高。治疗后OLP患者唾液MDA水平的降低无显著差异。
治疗后分析显示OLP病变有显著程度的恢复和疼痛缓解。因此，曲安奈德漱口水通过降低氧化应激是OLP患者的一种合适治疗方法。
