西西里岛移民人群中的结核病：一份实地报告。

Tuberculosis among Migrant Populations in Sicily: A Field Report.

作者信息

Prestileo Tullio, Pipitone Giuseppe, Sanfilippo Adriana, Ficalora Antonio, Natoli Giuseppe, Corrao Salvatore

机构信息

Infectious Disease Unit & Centre for Migration and Health, ARNAS Civico Di Cristina Benfratelli Hospital, Palermo, Italy.

StopTB Section of Sicily, Palermo, Italy.

出版信息

J Trop Med. 2021 Mar 30;2021:7856347. doi: 10.1155/2021/7856347. eCollection 2021.

DOI:10.1155/2021/7856347

PMID:33859702

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8024091/

Abstract

BACKGROUND

In the EU, tuberculosis (TB) mainly affects vulnerable people, including migrants. From 2014 to 2017, we have estimated the frequency of both tuberculosis and latent tuberculosis infection (LTBI) among the migrant population hosted in 41 reception centers in western Sicily (ITaCA network).

MATERIALS AND METHODS

All migrants were consecutively recruited for the screening of TB infection with physical examination and TST in 1,020 migrants and with IGRA in the others 2,690. The screening was carried out 4-8 weeks after landing in Sicily. For all migrants with a positive screening test, chest X-ray and smear examination were performed. LTBI was defined by positivity of TST or IGRA with negative X-ray chest, clinical, and smear examination. Active TB was defined by radiological and/or clinical and/or sputum positivity in a patient with a TST or IGRA positivity.

RESULTS

We evaluated a total of 3,710 migrants, of which 89% came from Sub-Saharan countries; 2,811 were males, 899 were females, with a median age of 22 years (IQR: 18-25). TB infection was diagnosed in 501 persons (13.5%) of which 440 (11.8%) had LTBI and 61 had active TB (1.6%): 1 had lymph node TB, 1 had intestinal TB, and 59 had pulmonary TB (38 sputum smear positive TB; no drug-resistant TB were observed).

CONCLUSIONS

TB screening is critical to early diagnosis and treatment.

摘要

背景

在欧盟，结核病（TB）主要影响包括移民在内的弱势群体。2014年至2017年期间，我们估算了西西里岛西部41个接待中心（ITaCA网络）收容的移民人群中结核病和潜伏性结核感染（LTBI）的发生率。

材料与方法

对所有移民进行连续招募，其中1020名移民通过体格检查和结核菌素皮肤试验（TST）筛查结核感染，其余2690名通过干扰素-γ释放试验（IGRA）进行筛查。筛查在抵达西西里岛4至8周后进行。对所有筛查试验呈阳性的移民进行胸部X光检查和涂片检查。LTBI的定义为TST或IGRA呈阳性，同时胸部X光、临床和涂片检查呈阴性。活动性结核病的定义为TST或IGRA呈阳性的患者出现放射学和/或临床和/或痰涂片阳性。

结果

我们共评估了3710名移民，其中89%来自撒哈拉以南国家；男性2811名，女性899名，中位年龄为22岁（四分位间距：18 - 25岁）。501人（13.5%）被诊断为结核感染，其中440人（11.8%）患有LTBI，61人患有活动性结核病（1.6%）：1人患有淋巴结结核，1人患有肠结核，59人患有肺结核（38例痰涂片阳性肺结核；未观察到耐药结核病）。