Ren Liang, Yang Jing, Wang Jun, Zhou Xuedong, Liu Chengcheng
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
J Immunol Res. 2021 Mar 30;2021:5557095. doi: 10.1155/2021/5557095. eCollection 2021.
Periodontitis is an oral chronic inflammatory disease that is initiated by periodontal microbial communities and requires disruption of the homeostatic responses. The prevalence of periodontal disease increases with age; more than 70% of adults 65 years and older have periodontal disease. A pathogenic microbial community is required for initiating periodontal disease. Dysbiotic immune-inflammatory response and bone remodeling are characteristics of periodontitis. The transcription factor forkhead box protein O1 (FOXO1) is a key regulator of a number of cellular processes, including cell survival and differentiation, immune status, reactive oxygen species (ROS) scavenging, and apoptosis. Although accumulating evidence indicates that FOXO1 activity can be induced by periodontal pathogens, the roles of FOXO1 in periodontal homeostasis and disease have not been well documented. The present review summarizes how the FOXO1 signaling axis can regulate periodontal bacteria-epithelial interactions, immune-inflammatory response, bone remodeling, and wound healing.
牙周炎是一种由牙周微生物群落引发的口腔慢性炎症性疾病，需要破坏体内平衡反应。牙周疾病的患病率随年龄增长而增加；65岁及以上的成年人中，超过70%患有牙周疾病。引发牙周疾病需要致病性微生物群落。失调的免疫炎症反应和骨重塑是牙周炎的特征。转录因子叉头框蛋白O1（FOXO1）是许多细胞过程的关键调节因子，包括细胞存活和分化、免疫状态、活性氧（ROS）清除和细胞凋亡。尽管越来越多的证据表明牙周病原体可诱导FOXO1活性，但FOXO1在牙周稳态和疾病中的作用尚未得到充分记录。本综述总结了FOXO1信号轴如何调节牙周细菌与上皮的相互作用、免疫炎症反应、骨重塑和伤口愈合。
