Trex2以多种方式对受损的复制叉做出反应。
Trex2 responds to damaged replication forks in diverse ways.
作者信息
Hasty Paul
机构信息
Department of Molecular Medicine and Institute of Biotechnology, The Cancer Therapy Research Center, Sam, Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, Texas, USA.
出版信息
Mol Cell Oncol. 2021 Feb 25;8(2):1881394. doi: 10.1080/23723556.2021.1881394. eCollection 2021.
Abstract
Three prime Repair Exonuclease 2 (Trex2) alters replication fork (RF) stability and mutation levels in cells defective for homologous recombination (HR). Trex2 has multiple functions that can either cause or supress RF instability in cells with different HR-defects. Why does Trex2 have such diverse effects on RF maintenance?
摘要
三磷酸修复外切核酸酶2（Trex2）可改变同源重组（HR）缺陷细胞中的复制叉（RF）稳定性和突变水平。Trex2具有多种功能，在具有不同HR缺陷的细胞中，这些功能既可能导致也可能抑制RF不稳定。为什么Trex2对RF维持有如此多样的影响？
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