Clinical Research Institute, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, China.
Small. 2021 Dec;17(52):e2103072. doi: 10.1002/smll.202103072. Epub 2021 Sep 24.
The development of cancer diagnostic imaging and treatment is a major concern worldwide. By integrating imaging and therapy into one theranostic nanoplatform for simultaneously detecting tumors, evaluating the targeting ability and timely monitoring therapeutic responses provide more opportunities for precision medicine. Among various theranostic nanosystems, a series of single-component nanoparticles (NPs) have been developed for "all-in-one" theranostics, which presents the unique properties of facile preparation, simple composition, defined structure, high reproducibility, and excellent biocompatibility. Specifically, utilizing single-component NPs for both diagnostics and therapeutics can reduce the possible numerous untoward side effects and risks to the living body. In this review, the recent progress of multifunctional single-component NPs in the applications of cancer theranostics is systematically summarized. Notably, the structure design, categories of NPs, targeted strategies, biomedical applications, potential barriers, challenges, and prospects for the future clinical practice of this rapidly growing field are discussed.
癌症诊断成像和治疗的发展是全世界关注的主要问题。通过将成像和治疗整合到一个治疗诊断纳米平台中，用于同时检测肿瘤、评估靶向能力和及时监测治疗反应，为精准医学提供了更多的机会。在各种治疗诊断纳米系统中，已经开发出一系列单组分纳米颗粒（NPs）用于“一站式”治疗诊断，其具有易于制备、组成简单、结构明确、高重现性和优异的生物相容性等独特特性。具体而言，利用单组分 NPs 进行诊断和治疗可以减少对生物体可能产生的许多不良副作用和风险。在本文中，系统总结了多功能单组分 NPs 在癌症治疗诊断应用中的最新进展。值得注意的是，讨论了该快速发展领域的结构设计、NPs 类别、靶向策略、生物医学应用、潜在障碍、挑战和未来临床实践的前景。
