Strickland Justin C, Garcia-Romeu Albert, Johnson Matthew W
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, Maryland 21224, United States.
ACS Pharmacol Transl Sci. 2020 Dec 29;4(2):472-478. doi: 10.1021/acsptsci.0c00187. eCollection 2021 Apr 9.
Mounting evidence supports the serotonin 2A receptor agonist psilocybin as a psychiatric pharmacotherapy. Little research has experimentally examined how session "set and setting" impacts subjective and therapeutic effects. We analyzed the effects of the musical genre played during sessions of a psilocybin study for tobacco smoking cessation. Participants ( = 10) received psilocybin (20-30 mg/70 kg) in two sessions, each with a different musical genre (Western classical versus overtone-based), with the order counterbalanced. Participants chose one genre for a third session (30 mg/70 kg). Mystical experiences scores tended to be higher in overtone-based sessions than in Western classical sessions. Six of ten participants chose the overtone-based music for a third session. Biologically confirmed smoking abstinence was similar based on musical choice, with a slight benefit for participants choosing the overtone-based playlist (66.7% versus 50%). These data call into question whether Western classical music typically used in psychedelic therapy holds a unique benefit. Broadly, we call for experimentally examining session components toward optimizing psychedelic therapeutic protocols.
越来越多的证据支持血清素2A受体激动剂裸盖菇素作为一种精神科药物疗法。很少有研究通过实验来检验疗程中的“心境和环境”如何影响主观和治疗效果。我们分析了在一项裸盖菇素戒烟研究疗程中播放的音乐类型的影响。参与者（n = 10）分两个疗程接受裸盖菇素（20 - 30 mg/70 kg），每个疗程播放不同的音乐类型（西方古典音乐与泛音音乐），顺序相互平衡。参与者为第三个疗程（30 mg/70 kg）选择一种音乐类型。基于泛音的疗程中神秘体验得分往往高于西方古典音乐疗程。十名参与者中有六人在第三个疗程选择了泛音音乐。基于音乐选择，生物学上确认的戒烟情况相似，选择泛音音乐播放列表的参与者略有优势（66.7%对50%）。这些数据让人质疑迷幻疗法中通常使用的西方古典音乐是否具有独特优势。总体而言，我们呼吁通过实验研究疗程组成部分，以优化迷幻治疗方案。
