Vitery R Jenny, Ortega Guillermo, Salazar C Blanca C
Facultad de Salud, Universidad Santiago de Cali, Cali, Colombia.
Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Pontificia Universidad Javeriana, Cali, Colombia.
Rev Chil Pediatr. 2020 Dec;91(6):924-929. doi: 10.32641/rchped.vi91i6.1403. Epub 2020 Oct 21.
The prepubertal stage is a critical period of body fat development, in which leptin and insulin re sistance has been associated, however, there are few studies in normal-weight prepubescents. Ob jective: To assess the relationship between leptin and body composition and insulin resistance in a group of normal-weight prepubescents.
Analytical cross-sectional study with 128 healthy prepubescents of normal weight, aged between 6 and 10 years. Height, weight, body mass index (BMI), body fat percentage (BFP), waist circumference (WC), and hip circumference (HC) were measured. Plasma leptin (ng/mL) and insulin (mU/L) were evaluated by immunoassay and glycemia (mmol/L) by enzymatic method. HOMA-IR was calculated. A comparison study and correlation analysis by sex were performed.
Females presented higher values than males of leptin (6.8 ± 5 vs 3.3 ± 3.7; p = 0.000), insulin (7.1 ± 4.5 vs 5.2 ± 2.5; p = 0.016), BFP (22.4 ± 4.3 vs 18.6 ± 3.9; p = 0.000), and HC (67 ± 5.7 vs 65.0 ± 4.5; p = 0.019), and a lower waist/hip ratio (0.84 ± 0.04 vs 0.88 ± 0.04; p = 0.000). Leptin correlations with anthropometric variables were significant in both sexes, with greater association in females. The association of HOMA-IR with leptin was similar in both sexes.
in normal-weight prepubescents aged between 6-10 years, there are sex differences in adiposity and leptin levels not associated with differences in BMI or insulin resistance. The greater association of leptin with adiposity in girls could be related to a high rate of adipogenesis induced by this hormone.
青春期前阶段是身体脂肪发育的关键时期，在此期间瘦素与胰岛素抵抗有关联，然而，针对正常体重青春期前儿童的研究较少。目的：评估一组正常体重青春期前儿童中瘦素与身体成分及胰岛素抵抗之间的关系。
对128名年龄在6至10岁的正常体重健康青春期前儿童进行分析性横断面研究。测量身高、体重、体重指数（BMI）、体脂百分比（BFP）、腰围（WC）和臀围（HC）。通过免疫测定法评估血浆瘦素（ng/mL）和胰岛素（mU/L），通过酶法评估血糖（mmol/L）。计算胰岛素抵抗稳态模型评估（HOMA-IR）。进行了按性别分组的比较研究和相关性分析。
女性的瘦素（6.8±5对3.3±3.7；p=0.000）、胰岛素（7.1±4.5对5.2±2.5；p=0.016）、BFP（22.4±4.3对18.6±3.9；p=0.000）和HC（67±5.7对65.0±4.5；p=0.019）值均高于男性，且腰臀比更低（0.84±0.04对0.88±0.04；p=0.000）。瘦素与人体测量学变量的相关性在两性中均显著，在女性中关联更强。HOMA-IR与瘦素的关联在两性中相似。
在6至10岁的正常体重青春期前儿童中，肥胖和瘦素水平存在性别差异，且与BMI或胰岛素抵抗差异无关。女孩中瘦素与肥胖的更强关联可能与该激素诱导的高脂肪生成率有关。
