Sainsbury Wellcome Centre, University College London, 25 Howland Street, London W1T 4JG, UK; Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
Sainsbury Wellcome Centre, University College London, 25 Howland Street, London W1T 4JG, UK; Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland; The National Institute of Water and Atmospheric Research, 301 Evans Bay Parade, Hataitai, Wellington 6021, New Zealand.
Neuron. 2021 Jun 2;109(11):1861-1875.e10. doi: 10.1016/j.neuron.2021.03.031. Epub 2021 Apr 15.
How sensory evidence is transformed across multiple brain regions to influence behavior remains poorly understood. We trained mice in a visual change detection task designed to separate the covert antecedents of choices from activity associated with their execution. Wide-field calcium imaging across the dorsal cortex revealed fundamentally different dynamics of activity underlying these processes. Although signals related to execution of choice were widespread, fluctuations in sensory evidence in the absence of overt motor responses triggered a confined activity cascade, beginning with transient modulation of visual cortex and followed by sustained recruitment of the secondary and primary motor cortex. Activation of the motor cortex by sensory evidence was modulated by animals' expectation of when the stimulus was likely to change. These results reveal distinct activation timescales of specific cortical areas by sensory evidence during decision-making and show that recruitment of the motor cortex depends on the interaction of sensory evidence and temporal expectation.
感觉证据如何在多个大脑区域中转化以影响行为仍未被很好地理解。我们在一个视觉变化检测任务中训练老鼠，该任务旨在将选择的隐蔽前因与与其执行相关的活动区分开来。背侧皮层的广角钙成像揭示了这些过程背后的活动的根本不同动态。尽管与选择执行相关的信号是广泛的，但在没有明显运动反应的情况下，感官证据的波动引发了一个受限的活动级联，从视觉皮层的瞬时调制开始，然后是次级和初级运动皮层的持续招募。动物对刺激可能发生变化的时间的预期会调节感官证据对运动皮层的激活。这些结果揭示了在决策过程中感觉证据对特定皮层区域的不同激活时间尺度，并表明运动皮层的募集取决于感觉证据和时间预期的相互作用。
