Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biochemistry, Faculty of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Life Sci. 2021 Aug 1;278:119500. doi: 10.1016/j.lfs.2021.119500. Epub 2021 Apr 20.
Cerium (IV) oxide (CeO) exhibit anti-inflammatory activity via scavenge free radicals and decreasing the oxygen species (ROS) production. Here we aimed to exhibit the therapeutic effect of this nanoparticle in experimental colitis models.
Cerium oxide nanoparticles (CeONPs) were synthesized via using UiO-66 as a precursor. We used dextran sodium sulfate (DSS) to induce colitis in experimental models to investigate the anti-inflammatory effect of CeONPs. Colitis models are divided into four groups to receive the treatment, including control, colitis, cerium oxide, and sulfasalazine. We evaluated the therapeutic effects of CeONPs for the increased colitis clinical symptoms and attenuated the histological damage to colon tissue in colitis.
This nanoparticle was significantly able to reduce the clinical symptoms of colitis. Moreover, CeONPs can enhance the disease activity index such as body lose weight, diarrhea, rectal bleeding, colon length, and spleen weight. Moreover, CeONPs showed a significant reduction in the histological characteristics of the colitis models.
These results suggest that CeONPs can be considered as promising therapeutic agents in treating the ulcerative colitis.
氧化铈（CeO）通过清除自由基和减少氧自由基（ROS）的产生来发挥抗炎作用。本研究旨在展示该纳米颗粒在实验性结肠炎模型中的治疗效果。
通过使用 UiO-66 作为前体合成氧化铈纳米颗粒（CeONPs）。我们使用葡聚糖硫酸钠（DSS）诱导实验模型中的结肠炎，以研究 CeONPs 的抗炎作用。结肠炎模型分为四组进行治疗，包括对照组、结肠炎组、氧化铈组和柳氮磺胺吡啶组。我们评估了 CeONPs 对增加的结肠炎临床症状和减轻结肠炎结肠组织的组织学损伤的治疗效果。
该纳米颗粒能显著减轻结肠炎的临床症状。此外，CeONPs 还能提高疾病活动指数，如体重减轻、腹泻、直肠出血、结肠长度和脾脏重量。此外，CeONPs 还显示出对结肠炎模型的组织学特征有显著的降低作用。
这些结果表明，CeONPs 可作为治疗溃疡性结肠炎的有前途的治疗剂。
