Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, China; Haikou Center for Medical Synchrotron Radiation Research, Haikou People's Hospital, Haikou, China.
Environ Pollut. 2021 Aug 1;282:116952. doi: 10.1016/j.envpol.2021.116952. Epub 2021 Mar 30.
Potential suppression of fertility due to mobile phone radiation remains a focus of researchers. We conducted meta-analyses on the effects of mobile phone radiation on sperm quality using recent evidence and propose some perspectives on this issue. Using the MEDLINE/PubMed, Embase, WOS, CENTRAL, and ClinicalTrials.gov databases, we retrieved and screened studies published before December 2020 on the effects of mobile phone use/mobile phone RF-EMR on sperm quality. Thirty-nine studies were included. Data quality and general information of the studies were evaluated and recorded. Sperm quality data (density, motility, viability, morphology, and DFI) were compiled for further analyses, and we conducted subgroup, sensitivity, and publication bias analyses. The pooled results of human cross-sectional studies did not support an association of mobile phone use and a decline in sperm quality. Different study areas contributed to the heterogeneity of the studies. In East Europe and West Asia, mobile phone use was correlated with a decline in sperm density and motility. Mobile phone RF-EMR exposure could decrease the motility and viability of mature human sperm in vitro. The pooled results of animal studies showed that mobile phone RF-EMR exposure could suppress sperm motility and viability. Furthermore, it reduced sperm density in mice, in rats older than 10 weeks, and in rats restrained during exposure. Differences regarding age, modeling method, exposure device, and exposure time contributed to the heterogeneity of animal studies. Previous studies have extensively investigated and demonstrated the adverse effects of mobile phone radiation on sperm. In the future, new standardized criteria should be applied to evaluate potential effects of mobile phone RF-EMR dosages. Further sperm-related parameters at the functional and molecular levels as well as changes in biological characteristics of germ cells should be evaluated. Moreover, the impact of mobile phone RF-EMR on individual organs should also be examined.
由于手机辐射导致生育能力下降的潜在问题仍然是研究人员关注的焦点。我们利用最新的证据对手机辐射对精子质量的影响进行了荟萃分析，并对这一问题提出了一些看法。我们使用 MEDLINE/PubMed、Embase、WOS、CENTRAL 和 ClinicalTrials.gov 数据库，检索并筛选了 2020 年 12 月之前发表的关于手机使用/手机射频电磁辐射对精子质量影响的研究。共纳入 39 项研究。评估和记录了研究的数据质量和一般信息。对精子质量数据（密度、活力、活力、形态和 DFI）进行了编译，以便进一步分析，并进行了亚组、敏感性和发表偏倚分析。来自人类横断面研究的汇总结果不支持手机使用与精子质量下降之间的关联。不同的研究区域导致了研究的异质性。在东欧和西亚，手机使用与精子密度和活力下降有关。手机射频电磁辐射暴露可能会降低体外成熟人类精子的活力和活力。来自动物研究的汇总结果表明，手机射频电磁辐射暴露可能会抑制精子的活力和活力。此外，它还降低了小鼠、10 周龄以上大鼠和暴露时受限制的大鼠的精子密度。年龄、建模方法、暴露装置和暴露时间的差异导致了动物研究的异质性。以前的研究已经广泛研究并证明了手机辐射对精子的不良影响。未来，应该应用新的标准化标准来评估手机射频电磁辐射剂量的潜在影响。还应该评估精子功能和分子水平的其他相关参数以及生殖细胞生物学特性的变化。此外，还应检查手机射频电磁辐射对个体器官的影响。
