Department of Public Health and Multidisciplinary Center for Research on Aging, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
STAR Institute, Simon Fraser University, Vancouver (BC) Canada.
J Affect Disord. 2021 May 15;287:433-440. doi: 10.1016/j.jad.2021.03.024. Epub 2021 Mar 13.
Older adults with bipolar disorder (BD) commonly present with cognitive deficits (e.g., attention, memory, verbal fluency). Concomitantly, older adults with BD commonly report subjective or perceived cognitive failures. For this study, we confirmed a 3-factor model of cognitive failures first validated with older adults free of mental illness (i.e., forgetfulness, distractibility, false triggering). We then computed a structural equation model (SEM) demonstrating the construct validity of perceived cognitive errors in relation to quality of life with BD. Use of SEM enabled us to measure quality of life broadly and germane to BD (i.e., well-being, life satisfaction, alcohol misuse, sleep quality).
We obtained responses from an international sample of 350 older adults with BD (M = 61.26 years of age, range 50-87), recruited via micro-targeted social media advertising. Most lived in Canada, the U.S., U.K., Ireland, Australia and South Africa.
As hypothesized, perceived cognitive failures were predicted by BD symptoms (depression and hypo/mania). And cognitive failures directly and indirectly predicted quality of life.
Future research is needed to replicate this QoL model over time with younger patients and those recruited using more traditional methods.
Perceived cognitive failures may not be strongly correlated with objective indices of cognitive deficits; nonetheless perceived cognitive failures are significantly associated with quality of life for older adults with BD. For both cognitive errors and BD symptoms, their indirect effect on quality of life (via suicide ideation) is greater than the direct effect.
患有双相情感障碍(BD)的老年人通常存在认知缺陷(例如,注意力、记忆力、语言流畅性)。同时,患有 BD 的老年人通常会报告主观或感知到的认知失败。在这项研究中,我们首先证实了一个经过验证的无精神疾病的老年人的认知失败三因素模型(即健忘、注意力分散、错误触发)。然后,我们计算了一个结构方程模型(SEM),展示了与 BD 相关的生活质量的感知认知错误的结构效度。使用 SEM 使我们能够广泛测量与 BD 相关的生活质量(即幸福感、生活满意度、酒精滥用、睡眠质量)。
我们通过微目标社交媒体广告招募了来自国际 350 名患有 BD 的老年人(M = 61.26 岁,年龄范围 50-87 岁)的样本。他们大多数人居住在加拿大、美国、英国、爱尔兰、澳大利亚和南非。
正如假设的那样,BD 症状(抑郁和轻躁狂/躁狂)预测了感知认知失败。认知失败直接和间接预测了生活质量。
未来的研究需要随着时间的推移,在更年轻的患者和使用更传统方法招募的患者中复制这个 QoL 模型。
感知认知失败与认知缺陷的客观指标可能没有很强的相关性;尽管如此,感知认知失败与患有 BD 的老年人的生活质量显著相关。对于认知错误和 BD 症状,它们对生活质量的间接影响(通过自杀意念)大于直接影响。