Department of Health Management and Economics, School of Public Health, Tehran University of Medical Science, Tehran, Iran.
Department of Health Services Management, Health Policy and Management Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
J Asthma. 2022 Jun;59(6):1203-1212. doi: 10.1080/02770903.2021.1917607. Epub 2021 May 8.
The EQ-5D is the most popular generic preference-based instrument used for asthma patients. This study aims to explore the psychometric properties of the EQ-5D-5L instrument in patients with asthma and identify the EQ-5D-5L scores in these patients.
PubMed, Scopus, Web of Science, Google Scholar and CEA Registry were searched with English language from 2009 until April 2020. Retrieved studies were checked against the inclusion criteria. Reference lists of the included articles were also reviewed. The quality of included articles was evaluated using Mitton checklist and the data were extracted by a reviewer and were checked by a second reviewer. Meta-analysis was done to calculate the overall scores based on type of asthma control.
A total of 17 articles were included. The EQ-5D-5L scores ranged from 0.45 to 0.93 and the VAS scores ranged from 35.67 to 83.80. The EQ-5D-5L is higher in well-controlled (0.88, 95% CI: 0.81-0.96, = 0.0001) than partly controlled (0.80, 95% CI: 0.74-0.85, = 0.001) and poorly controlled asthma (0.72, 95% CI: 0.67-0.77, = 0.01). Validity in two studies was weak and, in other studies, it was moderate to strong. Responsiveness of the EQ-5D-5L, that was shown in a study, was less than other generic instruments, and reliability was adequate in only study that had been reported. Ceiling effects were between 8.30% to 35%.
Higher score of the EQ-5D-5L was consistent with well-controlled asthma patients and those with lower severity of asthma. The assessment of psychometric properties of the EQ-5D-5L needs further observations.
EQ-5D 是最常用的用于哮喘患者的通用偏好量表。本研究旨在探讨 EQ-5D-5L 量表在哮喘患者中的心理测量特性，并确定这些患者的 EQ-5D-5L 评分。
使用英语从 2009 年至 2020 年 4 月在 PubMed、Scopus、Web of Science、Google Scholar 和 CEA 登记处进行检索。检查检索到的研究是否符合纳入标准。还审查了纳入文章的参考文献列表。使用 Mitton 清单评估纳入文章的质量，并由一名审查员提取数据，由另一名审查员进行检查。根据哮喘控制类型进行荟萃分析，计算总体得分。
共纳入 17 篇文章。EQ-5D-5L 评分范围为 0.45 至 0.93，VAS 评分范围为 35.67 至 83.80。控制良好（0.88，95%CI：0.81-0.96，=0.0001）的患者 EQ-5D-5L 评分高于部分控制（0.80，95%CI：0.74-0.85，=0.001）和控制不佳（0.72，95%CI：0.67-0.77，=0.01）的患者。两项研究的有效性较弱，而其他研究的有效性为中度至较强。一项研究显示 EQ-5D-5L 的反应性低于其他通用量表，而仅一项报告的研究表明可靠性足够。天花板效应在 8.30%至 35%之间。
EQ-5D-5L 评分较高与控制良好的哮喘患者和哮喘严重程度较低的患者一致。EQ-5D-5L 的心理测量特性评估需要进一步观察。
