Department of Health Management and Economics, School of Public Health, Tehran University of Medical Science, Tehran, Iran.
Health Policy and Management Research Center, Department of Health Services Management, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Expert Rev Pharmacoecon Outcomes Res. 2022 Mar;22(2):351-364. doi: 10.1080/14737167.2022.2011216. Epub 2022 Jan 11.
This study systematically reviews the validity, reliability, and responsiveness of the EQ-5D-5 L in studies of T2DM.
Relevant articles were retrieved by searching four databases, namely, the Web of Science, Scopus, PubMed, and Cochrane Library up to November 2020 with English language. All stages of the review conducted by two authors and disagreements were solved by consultation with a third reviewer.
Of the 1614 identified studies, 46 were remained for review. The EQ-5D-5 L mean scores ranged from 0.314 (0.4) (n = 141) for diabetic patients undergoing hemodialysis to 0.971 (0.082) (n = 56) for diabetic patient without retinopathy. Mean EQ-5D-5 L scores in men (0.847) were higher those in women (0.747). Construct validity and reliability was confirmed in the studies that reported the properties of the EQ-5D-5 L, and responsiveness reported in a study that was good. There were ceiling effects in seven studies. The overall utility value was higher in Japan (0.86, 95% CI: 0.80-0.92, = 0.0001) thanCanada (0.79, 95% CI: 0.78-0.80, = 0.81), and the United Kingdom (0.72, 95% CI: 0.64-0.79, = 0.0001).
Findings demonstrated validity, reliability of the EQ-5D-5 L in T2DM and the existence of ceiling effects. However, the assessment of responsiveness and sensitivity needs further observations.
本研究系统评价了 EQ-5D-5L 在 T2DM 研究中的有效性、可靠性和反应度。
通过检索 Web of Science、Scopus、PubMed 和 Cochrane Library 四个数据库，以英文检索截至 2020 年 11 月的相关文献，由两位作者进行所有阶段的综述，意见不一致时通过咨询第三位审稿人解决。
在 1614 项确定的研究中，有 46 项符合纳入标准。EQ-5D-5L 的平均评分范围从接受血液透析的糖尿病患者的 0.314（0.4）（n=141）到无视网膜病变的糖尿病患者的 0.971（0.082）（n=56）。男性（0.847）的平均 EQ-5D-5L 评分高于女性（0.747）。在报告 EQ-5D-5L 特性的研究中，确认了结构有效性和可靠性，在一项评价反应度的研究中，反应度被认为是良好的。有 7 项研究存在天花板效应。日本的总体效用值较高（0.86，95%CI：0.80-0.92， = 0.0001），而加拿大（0.79，95%CI：0.78-0.80， = 0.81）和英国（0.72，95%CI：0.64-0.79， = 0.0001）的效用值较低。
研究结果表明，EQ-5D-5L 在 T2DM 中具有有效性、可靠性和反应度，但还需要进一步观察其敏感性。
