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使用长柄骨水泥定制关节间隔器(CUMARS)治疗全髋关节置换术后假体周围感染和严重骨丢失

Management of peri-prosthetic joint infection and severe bone loss after total hip arthroplasty using a long-stemmed cemented custom-made articulating spacer (CUMARS).

作者信息

Quayle J, Barakat A, Klasan A, Mittal A, Chan G, Gibbs J, Edmondson M, Stott P

机构信息

Brighton and Sussex University Hospitals, Brighton, UK.

Department for Orthopaedics and Traumatology, Kepler University Hospital GmbH, Krankenhausstrasse 9, 4020, Linz, Austria.

出版信息

BMC Musculoskelet Disord. 2021 Apr 16;22(1):358. doi: 10.1186/s12891-021-04237-1.

Abstract

BACKGROUND

There is little evidence on techniques for management of peri-prosthetic infection (PJI) in the context of severe proximal femoral bone loss. Custom-made articulating spacers (CUMARS) utilising cemented femoral stems as spacers was described providing better bone support and longer survival compared to conventional articulating spacers. We retrospectively report our experience managing PJI by adaptation of this technique using long cemented femoral stems where bone loss precludes use of standard stems.

METHODS

Patients undergoing 1st stage revision for infected primary and revision THA using a cemented long stem (> 205 mm) and standard all-polyethylene acetabulum between 2011 and 2018 were identified. After excluding other causes of revision (fractures or aseptic loosening), Twenty-one patients remained out of total 721 revisions. Medical records were assessed for demographics, initial microbiological and operative treatment, complications, eradication of infection and subsequent operations. 2nd stage revision was undertaken in the presence of pain or subsidence.

RESULTS

Twenty-one patients underwent 1st stage revision with a cemented long femoral stem. Mean follow up was 3.9 years (range 1.7-7.2). Infection was eradicated in 15 (71.4%) patients. Two patients (9.5%) required repeat 1st stage and subsequently cleared their infection. Three patients (14.3%) had chronic infection and are on long term suppressive antibiotics. One patient (4.8%) was lost to follow up before 2 years. Complications occurred in seven patients (33%) during or after 1st stage revision. Where infection was cleared, 2nd stage revision was undertaken in 12 patients (76.5%) at average of 9 months post 1st stage. Five (23.8%) CUMARS constructs remained in-situ at an average of 3.8 years post-op (range 2.6-5.1).

CONCLUSIONS

Our technique can be used in the most taxing of reconstructive scenarios allowing mobility, local antibiotic delivery, maintenance of leg length and preserves bone and soft tissue, factors not afforded by alternative spacer options.

摘要

背景

在严重股骨近端骨丢失的情况下,关于假体周围感染(PJI)管理技术的证据很少。有人描述了使用骨水泥固定的股骨干作为间隔物的定制关节间隔物(CUMARS),与传统关节间隔物相比,它能提供更好的骨支撑和更长的使用寿命。我们回顾性报告了我们通过采用这种技术,使用长骨水泥固定股骨干来处理PJI的经验,在这种情况下,骨丢失使得无法使用标准股骨干。

方法

确定2011年至2018年间接受初次和翻修全髋关节置换术(THA)感染一期翻修的患者,使用骨水泥固定长柄(>205mm)和标准全聚乙烯髋臼。在排除其他翻修原因(骨折或无菌性松动)后,721例翻修患者中剩下21例。评估病历中的人口统计学、初始微生物学和手术治疗、并发症、感染根除情况及后续手术。在出现疼痛或下沉时进行二期翻修。

结果

21例患者接受了骨水泥固定长股骨干的一期翻修。平均随访3.9年(范围1.7 - 7.2年)。15例(71.4%)患者感染得到根除。2例(9.5%)患者需要重复一期翻修并随后清除感染。3例(14.3%)患者有慢性感染,正在接受长期抑制性抗生素治疗。1例(4.8%)患者在2年之前失访。7例(33%)患者在一期翻修期间或之后出现并发症。在感染清除的患者中,12例(76.5%)在一期翻修后平均9个月进行了二期翻修。5例(23.8%)CUMARS结构在术后平均3.8年(范围2.6 - 5.1年)仍保留原位。

结论

我们的技术可用于最具挑战性的重建情况,允许患者活动、局部抗生素递送、维持肢体长度并保留骨骼和软组织,这些是其他间隔物选项所不具备的因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc0/8052787/5641fbdc830a/12891_2021_4237_Fig1_HTML.jpg

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