Department of Medicine, Section of Dermatology and Venerology, University of Verona, Verona, Italy.
Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.
Ital J Pediatr. 2021 Apr 16;47(1):91. doi: 10.1186/s13052-021-00971-3.
Several studies have investigated the efficacy of balneotherapy in atopic dermatitis (AD), including a pediatric open randomized clinical trial conducted at the Comano thermal spring water center, which showed a significant reduction in AD severity and an improvement of the quality of life. However, so far many studies on balneotherapy in pediatric AD have included relatively small populations without identifying patients' characteristics associated with their response. The aim of the present study was to identify any features associated with the clinical response to the Comano thermal spring water balneotherapy in a large cohort of pediatric AD patients.
An observational study was conducted on 867 children aged ≤16 years (females 50.5%, mean patient's age 5.9 years, standard deviation ±3.6 years) with mild to severe AD who underwent balneotherapy at the Comano thermal spring water center (Comano, Trentino, Italy) from April to October 2014. Patients were stratified according to their disease severity, which was evaluated using five SCORing Atopic Dermatitis (SCORAD) categories before and immediately after a thermal spring water balneotherapy course. Potential characteristics associated with the patients' clinical response to Comano thermal spring water balneotherapy were investigated.
A statistically significant improvement in AD severity was observed after Comano thermal spring water balneotherapy (p < 0.0001). A significantly higher percentage of patients achieving improvement in AD severity was reported among children ≤4 years old (p < 0.0001) with early-onset AD (p < 0.0001), severe AD (p < 0.0001) or coexistent reported food allergies (p < 0.01). The therapy was well tolerated, and no relevant adverse effects were reported during the treatment course.
Comano thermal spring water balneotherapy is a safe complementary treatment for pediatric patients with AD, as it was able to reduce the disease severity, especially in children ≤4 years old, with early onset AD, severe AD or concomitant food allergies.
多项研究调查了水疗对特应性皮炎（AD）的疗效，包括在卡莫温泉水中心进行的儿科开放性随机临床试验，该试验显示 AD 严重程度显著降低，生活质量得到改善。然而，迄今为止，许多关于儿科 AD 水疗的研究都包括了相对较小的人群，没有确定与患者反应相关的特征。本研究旨在确定在大样本儿科 AD 患者中，与卡莫温泉水疗临床反应相关的任何特征。
对 2014 年 4 月至 10 月在意大利特伦托卡莫温泉水中心接受水疗的 867 名≤16 岁（女性占 50.5%，平均患者年龄 5.9 岁，标准差±3.6 岁）的轻至重度 AD 儿童进行了一项观察性研究。根据疾病严重程度对患者进行分层，使用五个 SCORing 特应性皮炎（SCORAD）类别在接受温泉水疗前后进行评估。研究了与患者对卡莫温泉水疗临床反应相关的潜在特征。
卡莫温泉水疗后 AD 严重程度显著改善（p<0.0001）。在≤4 岁（p<0.0001）、早发性 AD（p<0.0001）、重度 AD（p<0.0001）或同时伴有报告食物过敏（p<0.01）的儿童中，报告 AD 严重程度改善的患者比例显著更高。治疗耐受性良好，在治疗过程中未报告任何相关不良反应。
卡莫温泉水疗是儿科 AD 患者的一种安全的补充治疗方法，因为它能够降低疾病严重程度，特别是在≤4 岁、早发性 AD、重度 AD 或伴有食物过敏的儿童中。
