Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
J Dermatolog Treat. 2011 Dec;22(6):366-71. doi: 10.3109/09546634.2010.512950. Epub 2011 Jan 22.
No controlled studies have investigated whether balneotherapy is effective in atopic dermatitis (AD).
To investigate the efficacy and safety of balneotherapy performed at Comano spa (Trentino, Italy) compared to topical corticosteroids (TCS) in the treatment of AD.
This was an open, randomized, clinical trial including 104 children (aged 1-14 years) with mild to moderate AD who were assigned either to balneotherapy (n = 54) or TCS (n = 50) once daily for 2 weeks. AD severity and quality of life were measured using the SCORAD, investigator global assessment (IGA), patients' self global assessment (PSGA), children's dermatology life quality index (CDLQI) and family dermatitis impact questionnaire (FDIQ). Subjective measures were re-evaluated 4 months after the end of therapy.
Balneotherapy and TCS resulted in a significant reduction of all parameters at week 2. TCS were more effective than balneotherapy regarding SCORAD (46% ± 7.71 vs 26% ± 9.4, mean ± SD; p < 0.03). In contrast, IGA, PSGA, CDLQI and FDIQ improvement was similar. At month 4, the number and duration of relapses were less in patients treated with balneotherapy compared to those treated with TCS (p <0.0001).
Balneotherapy at Comano spa appears to be beneficial in children with mild to moderate AD.
尚无对照研究调查矿泉疗法对特应性皮炎（AD）是否有效。
调查科马诺温泉（意大利特伦蒂诺）矿泉疗法与局部皮质类固醇（TCS）治疗 AD 的疗效和安全性。
这是一项开放、随机、临床试验，纳入了 104 名年龄在 1-14 岁之间的轻至中度 AD 患儿，他们被分配至矿泉疗法组（n=54）或 TCS 组（n=50），每日一次，治疗 2 周。使用 SCORAD、研究者总体评估（IGA）、患者自我总体评估（PSGA）、儿童皮肤病生活质量指数（CDLQI）和家庭皮炎影响问卷（FDIQ）评估 AD 严重程度和生活质量。治疗结束后 4 个月再次评估主观指标。
矿泉疗法和 TCS 均能在第 2 周显著降低所有参数。与矿泉疗法相比，TCS 对 SCORAD 的疗效更好（46%±7.71%比 26%±9.4%，均值±标准差；p<0.03）。相比之下，IGA、PSGA、CDLQI 和 FDIQ 的改善情况相似。治疗 4 个月时，与 TCS 组相比，矿泉疗法组患者的复发次数和持续时间较少（p<0.0001）。
科马诺温泉矿泉疗法似乎对轻至中度 AD 患儿有益。
