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评价胶束 ExtraOx 形式和油溶液中 C 在小鼠体内的生物分布。

Evaluation of the C biodistribution in mice in a micellar ExtraOx form and in an oil solution.

机构信息

Pavlov First Saint Petersburg State Medical University, L'va Tolstogo ulitsa 6-8, Saint Petersburg, Russia, 197022.

Institute of Chemistry, Saint Petersburg State University, Universitetskii prospect 26, Saint Petersburg, Russia, 198504.

出版信息

Sci Rep. 2021 Apr 16;11(1):8362. doi: 10.1038/s41598-021-87014-3.

DOI:10.1038/s41598-021-87014-3
PMID:33863918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8052328/
Abstract

The article is devoted to the study of the pharmacokinetics of fullerene C in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C in the micellar form is higher than that in an oil solution.

摘要

本文致力于研究富勒烯 C 在油相和胶束相中的药物动力学，分析其在血液、肝脏、肺、肾、心脏、脑、肾上腺、胸腺、睾丸和脾脏中的含量。研究发现，C 在肝脏和肾上腺中的积累量最高。研究结果表明，胶束形式的 C 的生物利用度高于油溶液中的生物利用度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ceca0a25fed6/41598_2021_87014_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ea57fbfee6a4/41598_2021_87014_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/15813fa09f7b/41598_2021_87014_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/4f90d507d054/41598_2021_87014_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ef6298b5e6e4/41598_2021_87014_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/f9c5330981d1/41598_2021_87014_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/dd6776d41e55/41598_2021_87014_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/39ae68cc6e7f/41598_2021_87014_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ad23ff9f41ca/41598_2021_87014_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ceca0a25fed6/41598_2021_87014_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ea57fbfee6a4/41598_2021_87014_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/3a048d4f26c8/41598_2021_87014_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/1dc9db6e82c4/41598_2021_87014_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/15813fa09f7b/41598_2021_87014_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/4f90d507d054/41598_2021_87014_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ef6298b5e6e4/41598_2021_87014_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/f9c5330981d1/41598_2021_87014_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/dd6776d41e55/41598_2021_87014_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/39ae68cc6e7f/41598_2021_87014_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ad23ff9f41ca/41598_2021_87014_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/8052328/ceca0a25fed6/41598_2021_87014_Fig11_HTML.jpg

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