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Behavioural evidence for simultaneous dual changes of 5-HT receptor subtypes: mode of antidepressant action?

作者信息

Pericić D, Manev H

机构信息

Department of Experimental Biology and Medicine, Rudjer Bosković Institute, Zagreb, Yugoslavia.

出版信息

Life Sci. 1988;42(25):2593-601. doi: 10.1016/0024-3205(88)90328-1.

DOI:10.1016/0024-3205(88)90328-1
PMID:3386401
Abstract

Effects of the classic antidepressant imipramine and of an imipramine-like potential antidepressant dihydroergosine were studied in mice, rats and guinea pigs using behavioural models associated with the activation of 5-HT2 and 5-HT1 receptors respectively. Both drugs given in a single dose inhibited the 5-HT2 mediated behaviour for 24 and 48 h respectively and simultaneously stimulated 5-HT1 mediated behaviour for 6 days. Blockade of 5-HT2 receptors could have reduced their inhibitory influence on 5-HT1 receptors. We propose that the interplay between the two receptor subtypes controls the serotoninergic transmission. This idea throws a new light on the mode of action of antidepressants.

摘要

相似文献

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2
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引用本文的文献

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Psychopharmacology (Berl). 2003 Jun;167(4):373-9. doi: 10.1007/s00213-002-1357-y. Epub 2003 Apr 15.
2
Possible antidepressant dihydroergosine preferentially binds to 5-HT1B receptor sites in the rat hippocampus.可能具有抗抑郁作用的双氢麦角碱优先与大鼠海马体中的5-HT1B受体位点结合。
J Neural Transm Gen Sect. 1993;92(1):1-9. doi: 10.1007/BF01245157.
3
Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats.
重复轻度应激及两种抗抑郁治疗对大鼠5HT1C受体激活后行为反应的影响。
Psychopharmacology (Berl). 1993;110(1-2):140-4. doi: 10.1007/BF02246963.
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Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists.双氢麦角碱对γ-氨基丁酸拮抗剂诱发惊厥的双物种依赖性效应。
J Neural Transm Gen Sect. 1990;79(1-2):125-9. doi: 10.1007/BF01251007.
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Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants.5-羟色胺（5-HT）受体激动剂、拮抗剂或抗抑郁药长期治疗后，大鼠中5-HT1A和5-HT2而非5-HT1C受体介导行为的减弱。
Psychopharmacology (Berl). 1991;105(2):219-24. doi: 10.1007/BF02244313.
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Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour.噻奈普汀对应激诱导的行为缺陷和5-羟色胺依赖性行为的影响。
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