双氢麦角碱对γ-氨基丁酸拮抗剂诱发惊厥的双物种依赖性效应。
Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists.
作者信息
Pericić D, Manev H
机构信息
Department of Experimental Biology and Medicine, Rudjer Bosković Institute, Zagreb, Yugoslavia.
出版信息
J Neural Transm Gen Sect. 1990;79(1-2):125-9. doi: 10.1007/BF01251007.
PMID:2153387
Abstract
The potential antidepressant dihydroergosine enhanced the convulsive properties of picrotoxin and bicuculline in rats and diminished them in mice. The possibility of dihydroergosine modulating species-dependently GABA/benzodiazepine receptors is suggested.
摘要
潜在的抗抑郁药双氢麦角碱增强了大鼠中匹鲁卡品和荷包牡丹碱的惊厥特性，而在小鼠中则减弱了它们的惊厥特性。这提示了双氢麦角碱可能以物种依赖的方式调节γ-氨基丁酸/苯二氮䓬受体。
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