Tababi Ramzi, Khsiba Amal, Mahmoudi Moufida, Ben Mohamed Asma, Yakoubi Manel, Gharbi Ghada, Chaabane Abir, Chelbi Emna, Medhioub Mouna, Hamzaoui Mohamed Lamine
Gastroenterology Department, Mohamed Taher Maamouri University Hospital Nabeul, Mrezga, Nabeul, Tunisia.
Pathology Department, Mohamed Taher Maamouri University Hospital Nabeul, Mrezga, Nabeul, Tunisia.
F1000Res. 2024 Dec 16;13:1019. doi: 10.12688/f1000research.155815.2. eCollection 2024.
Gastric metastasis from melanoma is rare and often presents as an unexpected finding, rarely revealing an underlying primary skin melanoma.
We report a case of a 62-year-old male who presented with abdominal pain, dyspepsia, anorexia, and weight loss. On physical examination abdominal masses and hepatomegaly were detected. Radiological imaging showed widespread masses in the abdominal and thoracic regions. Upper gastrointestinal endoscopy identified an umbilicated protruded lesion with central dark pigmentation at the antro-fundic junction. Histopathological examination and immunohistochemical staining were consistent with melanoma. A subsequent rigorous skin examination uncovered a primary malignant skin melanoma. Due to worsening general condition, the patient received palliative hospice care.
This report highlights the critical need for vigilant skin examination when encountering gastric lesions with dark pigmentation, which led to the identification of initially undetected cutaneous melanoma.
黑色素瘤的胃转移罕见,常表现为意外发现,很少能揭示潜在的原发性皮肤黑色素瘤。
我们报告一例62岁男性,表现为腹痛、消化不良、厌食和体重减轻。体格检查发现腹部肿块和肝肿大。放射影像学显示腹部和胸部广泛存在肿块。上消化道内镜检查发现胃窦-胃底交界处有一个中央色素沉着的脐状突出病变。组织病理学检查和免疫组化染色结果与黑色素瘤一致。随后的严格皮肤检查发现了原发性恶性皮肤黑色素瘤。由于全身状况恶化,患者接受了姑息性临终关怀。
本报告强调,遇到有色素沉着的胃部病变时,必须进行仔细的皮肤检查,这有助于发现最初未被检测到的皮肤黑色素瘤。