Tulane National Primate Research Center, Tulane University, Covington, LA, USA; Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA.
Tulane National Primate Research Center, Tulane University, Covington, LA, USA.
Virology. 2021 Jul;559:100-110. doi: 10.1016/j.virol.2021.03.019. Epub 2021 Apr 9.
While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8 cells prior to rechallenge with a heterologous ZIKV isolate. The initial challenge during pregnancy produced transcriptional signatures suggesting complex patterns of immune modulation as well as neutralizing antibodies that persisted until rechallenge, which all animals efficiently controlled, demonstrating that the primary infection conferred adequate protection. The secondary challenge promoted activation of innate and adaptive immune cells, possibly suggesting a brief period of infection prior to clearance. These data confirm that ZIKV infection during pregnancy induces sufficient immunity to protect from a secondary challenge and suggest that this protection is not dependent on CD8 T cells.
虽然细胞免疫是对寨卡病毒（ZIKV）感染的免疫反应的一个重要组成部分，但这些反应在怀孕期间的效果尚不清楚。在这里，我们测试了 CD8 淋巴细胞在 4 只猕猴中的保护能力，其中 2 只猕猴在接受异源 ZIKV 分离株再次攻击之前被耗尽了 CD8 细胞。怀孕期间的初次感染产生了转录特征，表明存在复杂的免疫调节模式以及中和抗体，这些抗体一直持续到再次感染，所有动物都有效地控制了再次感染，表明初次感染提供了足够的保护。二次感染促进了先天和适应性免疫细胞的激活，可能提示在清除之前有一个短暂的感染期。这些数据证实，怀孕期间的寨卡病毒感染会诱导足够的免疫力来防止二次感染，并表明这种保护不依赖于 CD8 T 细胞。
