Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.
Department of Pediatric, The Third People's Hospital of Shenzhen, Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
BMC Infect Dis. 2021 Apr 17;21(1):365. doi: 10.1186/s12879-021-06037-3.
Coronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission.
A total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared.
Fever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. The IA patients were more likely to have lower-than-normal levels of lymphocyte count and percentage and to have higher-than-normal levels of activated partial thromboplastin time, prothrombin time, serum C-reactive protein, and serum procalcitonin, while the COVID-19 patients had higher odds of having lower-than-normal levels of neutrophil count and percentage.
This study suggests that influenza A is more symptomatic than COVID-19 for children and might be an overall more severe infection at the time of admission.
新型冠状病毒病 2019（COVID-19）与甲型流感（IA）具有相似的症状，但了解这两种感染在入院时的临床特征方面的差异更有价值。
共纳入 71 对年龄匹配的儿科 IA 和 COVID-19 患者，并比较其入院时的临床数据。
发热、咳嗽、鼻塞和恶心/呕吐是两种感染最常见的入院时症状，但 COVID-19 中发生的频率较低。IA 患者更可能出现低于正常水平的淋巴细胞计数和百分比，以及高于正常水平的活化部分凝血活酶时间、凝血酶原时间、血清 C 反应蛋白和血清降钙素原，而 COVID-19 患者更可能出现低于正常水平的中性粒细胞计数和百分比。
本研究表明，IA 在儿童中的症状比 COVID-19 更明显，且在入院时可能是一种更严重的感染。
