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地高辛之谜——是否需要验证?

'Digoxin conundrum - Time for validation?'.

机构信息

C.E.O. & Chief Cardiac Surgeon, National Heart Institute, 49-50 Community Centre, East of Kailash, New Delhi, 110065, India.

出版信息

Indian Heart J. 2021 Mar-Apr;73(2):242-243. doi: 10.1016/j.ihj.2021.01.019. Epub 2021 Jan 29.

DOI:10.1016/j.ihj.2021.01.019
PMID:33865529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8065360/
Abstract

Despite no incontrovertible data, Digoxin use has been demonised. As a consequence, a lot of patients, stable on Digoxin, have been taken off it and offered alternative drugs. However, there is some light at the end of the tunnel for Digoxin, with the reporting of RATE-AF Trial at the recent European Society of Cardiology Congress. Compared to Bisoprolol, Digoxin use was associated with statistically significantly greater improvements in symptomatology and NT ProBNP levels making Digoxin a first line drug for rate control in permanent AF.

摘要

尽管没有确凿的数据,但地高辛的使用已被妖魔化。结果,许多服用地高辛的稳定患者已被停药并改用其他药物。然而,地高辛在隧道尽头出现了一线曙光,最近在欧洲心脏病学会大会上报告了 RATE-AF 试验。与比索洛尔相比,地高辛的使用与症状和 NT ProBNP 水平的统计学显著改善相关,使地高辛成为永久性房颤患者的一线控制心率药物。

相似文献

1
'Digoxin conundrum - Time for validation?'.地高辛之谜——是否需要验证?
Indian Heart J. 2021 Mar-Apr;73(2):242-243. doi: 10.1016/j.ihj.2021.01.019. Epub 2021 Jan 29.
2
Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial.地高辛与比索洛尔控制心房颤动患者心率对生活质量影响的比较:RATE-AF 随机临床试验。
JAMA. 2020 Dec 22;324(24):2497-2508. doi: 10.1001/jama.2020.23138.
3
[Digoxin and atrial fibrillation in 2016].[2016年的地高辛与心房颤动]
Rev Med Suisse. 2016 Oct 19;12(535):1758-1760.
4
Mortality in heart failure with atrial fibrillation: Role of digoxin and diuretics.心力衰竭伴心房颤动患者的死亡率:地高辛和利尿剂的作用。
Eur J Clin Invest. 2018 Nov;48(11):e13014. doi: 10.1111/eci.13014. Epub 2018 Aug 23.
5
Comparison of beta blocker and digoxin alone and in combination for management of patients with atrial fibrillation and heart failure.β受体阻滞剂与地高辛单独及联合应用于房颤合并心力衰竭患者治疗的比较。
Am J Cardiol. 2009 Jan 15;103(2):248-54. doi: 10.1016/j.amjcard.2008.09.064. Epub 2008 Nov 7.
6
When, and when not, to use digoxin in the elderly.老年人何时以及何时不宜使用地高辛。
Drugs Aging. 1997 Jun;10(6):411-20. doi: 10.2165/00002512-199710060-00002.
7
In older patients with permanent AF and HF, digoxin and bisoprolol did not differ for QoL at 6 mo.在永久性房颤和心衰的老年患者中,地高辛和比索洛尔在 6 个月时的生活质量方面没有差异。
Ann Intern Med. 2021 Jun;174(6):JC69. doi: 10.7326/ACPJ202106150-069. Epub 2021 Jun 1.
8
Use of digoxin for heart failure and atrial fibrillation in elderly patients.地高辛在老年患者心力衰竭和心房颤动中的应用。
Am J Geriatr Pharmacother. 2010 Oct;8(5):419-27. doi: 10.1016/j.amjopharm.2010.10.001.
9
Digoxin.地高辛
Prog Cardiovasc Dis. 2002 Jan-Feb;44(4):251-66. doi: 10.1053/pcad.2002.31591.
10
Role of Digoxin in Atrial Fibrillation.地高辛在心房颤动中的作用。
J Pharm Pract. 2017 Aug;30(4):434-440. doi: 10.1177/0897190016642361. Epub 2016 Apr 10.

本文引用的文献

1
Digoxin in Atrial Fibrillation?: Leave it Out of the Medicine Cabinet.地高辛用于房颤?:别把它放进药柜了。
J Am Coll Cardiol. 2018 Mar 13;71(10):1075-1077. doi: 10.1016/j.jacc.2018.01.015.
2
A review of rate control in atrial fibrillation, and the rationale and protocol for the RATE-AF trial.心房颤动心率控制综述以及RATE-AF试验的基本原理和方案。
BMJ Open. 2017 Jul 20;7(7):e015099. doi: 10.1136/bmjopen-2016-015099.
3
Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data.地高辛的安全性和有效性:观察性和对照试验数据的系统评价与荟萃分析
BMJ. 2015 Aug 30;351:h4451. doi: 10.1136/bmj.h4451.
4
The effect of digoxin on mortality and morbidity in patients with heart failure.地高辛对心力衰竭患者死亡率和发病率的影响。
N Engl J Med. 1997 Feb 20;336(8):525-33. doi: 10.1056/NEJM199702203360801.