从出生到成年一直限制热量摄入或给予 cafeteria 饮食会增加 Wistar 大鼠焦虑和运动中对麻黄碱的敏感性。
Caloric restriction or cafeteria diet from birth to adulthood increases the sensitivity to ephedrine in anxiety and locomotion in Wistar rats.
机构信息
Laboratório de Nutrição Experimental, Departamento de Nutrição, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367 (Km 583), Campus JK, n 5000, Alto da Jacuba, Diamantina, Brasil; Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367 (Km 583), Campus JK, n 5000, Alto da Jacuba, Diamantina, Brasil; Programa Multicêntrico de Pós-graduação em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367 (Km 583), Campus JK, n 5000, Alto da Jacuba, Diamantina, Brasil.
Laboratório de Nutrição Experimental, Departamento de Nutrição, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367 (Km 583), Campus JK, n 5000, Alto da Jacuba, Diamantina, Brasil; Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367 (Km 583), Campus JK, n 5000, Alto da Jacuba, Diamantina, Brasil.
出版信息
Physiol Behav. 2021 Jul 1;236:113430. doi: 10.1016/j.physbeh.2021.113430. Epub 2021 Apr 15.
INTRODUCTION
Obesity and undernutrition, consequences of malnutrition, have been linked to the development of mental illnesses. Both states have been linked to increased sensitivity to some drugs, but there are few data for this association considering drugs with noradrenergic-dopaminergic action.
OBJECTIVE
To evaluate the nutritional status of animals treated with either a caloric restriction (CR) or cafeteria (CAF) diet from birth and their behavior after ephedrine application.
METHODS
During the lactation period, 12 litters of Wistar rats (dam + 8 pups) were fed one of three diets: control (n = 4), CR (n = 4), and CAF (n = 4). After weaning, the males were placed in individual boxes and received the same diet as their respective dams. Nutritional assessments were performed after weaning and in adulthood. In adulthood, males received either saline or ephedrine (20 mg/kg) and underwent behavioral tests including the elevated plus-maze, open-field, and food intake tests.
RESULTS
The CR group exhibited higher serum high-density lipoprotein (HDL) levels and lower food and caloric intake, weight gain, and fat mass than the control group. The CAF group exhibited lower food intake and higher fat caloric intake, fat mass, and serum low-density lipoprotein (LDL), triglyceride, total cholesterol, and hepatic lipid levels than the control group. These results indicated that the CR and CAF groups had developed undernutrition and obesity, respectively. In the elevated plus-maze and open-field tests, the CR and CAF groups showed lower anxiety-like behaviors than the control group after ephedrine application. This result indicates that the animal's nutritional status (undernutrition or obesity) can enhance ephedrine sensitivity.
CONCLUSION
The CR group exhibited undernutrition, whereas the CAF group exhibited obesity. Ephedrine altered anxiety and locomotion in animals that received the CR and CAF diets in manner different than that observed in animals receiving the standard diet.
简介
肥胖和营养不良是营养不良的后果，与精神疾病的发展有关。这两种状态都与某些药物的敏感性增加有关，但考虑到具有去甲肾上腺素-多巴胺作用的药物，针对这种关联的数据很少。
目的
评估从出生起就接受热量限制（CR）或自助餐厅（CAF）饮食治疗的动物的营养状况及其应用麻黄素后的行为。
方法
在哺乳期，12 窝 Wistar 大鼠（母鼠+8 只幼鼠）分别喂食三种饮食中的一种：对照（n=4）、CR（n=4）和 CAF（n=4）。断奶后，雄性大鼠被放置在单独的盒子中，并接受与各自母鼠相同的饮食。断奶后和成年后进行营养评估。成年后，雄性大鼠接受生理盐水或麻黄素（20mg/kg），并进行行为测试，包括高架十字迷宫、旷场和食物摄入测试。
结果
CR 组的血清高密度脂蛋白（HDL）水平较高，而对照组的食物和热量摄入、体重增加和脂肪量较低。CAF 组的食物摄入量较低，而脂肪热量摄入、脂肪量、血清低密度脂蛋白（LDL）、甘油三酯、总胆固醇和肝脂质水平较高，与对照组相比。这些结果表明，CR 和 CAF 组分别出现了营养不良和肥胖。在高架十字迷宫和旷场测试中，与对照组相比，应用麻黄素后，CR 和 CAF 组的焦虑样行为较低。这表明动物的营养状况（营养不良或肥胖）可以增强麻黄素的敏感性。
结论
CR 组表现出营养不良，而 CAF 组表现出肥胖。与接受标准饮食的动物相比，CR 和 CAF 饮食组的动物的焦虑和运动能力因麻黄素而发生改变。
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