Cafeteria diet during lactation and/or post-lactation altered lipid profile/lipid peroxidation and increased anxiety-like behavior in male rat offspring.

: Evaluate the impact of the cafeteria diet during lactation and/or post-lactation on physiological parameters and anxiety in the offspring of Wistar rats. : Male offspring of Wistar rats ( = 60) were randomized into four groups: Control (C), Lactation Cafeteria (LC), Post-lactation Cafeteria (PC) and Total Cafeteria (TC). Later in adult life the animals were submitted to the behavioral (elevated plus-maze and open field) and biological (body weight, consumption and food preference, glycemia, total cholesterol, LDL cholesterol, HDL cholesterol, VLDL cholesterol, triglycerides, total proteins, urea, creatinine, bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, serum protein, and oxidative stress) evaluations. The data were submitted to ANOVA, followed by the Newman-Keuls test (< 0.05). : Animals treated with the cafeteria diet presented greater weight measurements compared to the control group. Triglyceride levels were higher in the PC group than in the other groups. MDA levels were higher in the PC and TC group than CL and C. The animals of the PC and TC groups presented higher levels of anxiety compared to the C and LC groups. No significant differences due to diet were observed in the locomotor and exploratory behaviors. : The cafeteria diet ingestion was capable of triggering biological and behavioral alterations in rats.