Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, Australia.
Cognition and Philosophy Lab, Philosophy Department, Monash University, Clayton, Australia.
Neurosci Biobehav Rev. 2021 Aug;127:572-592. doi: 10.1016/j.neubiorev.2021.04.013. Epub 2021 Apr 15.
Deficits in social processing (SP) have been proposed to underpin interpersonal dysfunction in both Borderline Personality Disorder (BPD) and Substance Use Disorders (SUD). This study aimed to explore potential transdiagnostic cognitive and behavioral phenotypes of these disorders utilizing the NIMH Research Domain Criteria 'Systems for Social Processes'. A systematic review and meta-analysis of the published research was conducted on 134 studies identified through our database searches. Four meta-analyses were conducted, which revealed significant overlapping deficits in the ability to identify facial emotions and infer the mental states of others in both BPD and SUD. Further, people with BPD displayed a higher ostracism effect following perceived social exclusion. Systematically reviewed studies also revealed significant dysfunction amongst individuals with BPD and SUD across both self and other SP constructs, which were broadly similar in magnitude. Taken together, these results support the proposition that SP dysfunction may be considered a core transdiagnostic phenotype of BPD and SUD.
社会处理缺陷（SP）被认为是边缘型人格障碍（BPD）和物质使用障碍（SUD）中人际功能障碍的基础。本研究旨在利用 NIMH 研究领域标准“社会处理系统”探索这些障碍的潜在跨诊断认知和行为表型。通过我们的数据库搜索，对 134 项已发表的研究进行了系统综述和荟萃分析。进行了四项荟萃分析，结果表明，在 BPD 和 SUD 中，识别面部情绪和推断他人心理状态的能力存在显著重叠缺陷。此外，在感知到社会排斥后，BPD 患者表现出更高的排斥效应。系统综述研究还表明，BPD 和 SUD 患者在自我和他人的 SP 结构中均存在显著的功能障碍，其严重程度大致相似。综上所述，这些结果支持了这样一种观点，即 SP 功能障碍可能被认为是 BPD 和 SUD 的核心跨诊断表型。
