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The "Hygiene Hypothesis" and the Lessons Learnt From Farm Studies.

作者信息

von Mutius Erika

机构信息

Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.

Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Institute of Asthma and Allergy Prevention, Munich, Germany.

出版信息

Front Immunol. 2021 Mar 18;12:635522. doi: 10.3389/fimmu.2021.635522. eCollection 2021.

DOI:10.3389/fimmu.2021.635522
PMID:33868259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8044987/
Abstract
摘要

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本文引用的文献

1
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma.生命早期肠道微生物组的成熟促进了保护性农场效应对儿童哮喘的作用。
Nat Med. 2020 Nov;26(11):1766-1775. doi: 10.1038/s41591-020-1095-x. Epub 2020 Nov 2.
2
Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention.哮喘的一级预防：从风险和保护因素到有针对性的预防策略。
Lancet. 2020 Sep 19;396(10254):854-866. doi: 10.1016/S0140-6736(20)31861-4. Epub 2020 Sep 7.
3
Cow's milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells.牛奶蛋白 β-乳球蛋白通过将复合铁靶向免疫细胞赋予对过敏的抵抗力。
J Allergy Clin Immunol. 2021 Jan;147(1):321-334.e4. doi: 10.1016/j.jaci.2020.05.023. Epub 2020 May 30.
4
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.阿米什和哈特派农场儿童的先天免疫与哮喘风险
N Engl J Med. 2016 Aug 4;375(5):411-421. doi: 10.1056/NEJMoa1508749.
5
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.农田尘螨和内毒素通过肺上皮细胞中 A20 的诱导来预防过敏。
Science. 2015 Sep 4;349(6252):1106-10. doi: 10.1126/science.aac6623.
6
Increased food diversity in the first year of life is inversely associated with allergic diseases.生命的第一年增加食物多样性与过敏疾病呈负相关。
J Allergy Clin Immunol. 2014 Apr;133(4):1056-64. doi: 10.1016/j.jaci.2013.12.1044. Epub 2014 Feb 6.
7
The combined effects of family size and farm exposure on childhood hay fever and atopy.家庭规模和农场暴露对儿童花粉症和特应性的综合影响。
Pediatr Allergy Immunol. 2013 May;24(3):293-8. doi: 10.1111/pai.12053. Epub 2013 Apr 3.
8
Exposure to farming environments in childhood and asthma and wheeze in rural populations: a systematic review with meta-analysis.儿童时期接触农业环境与农村人群哮喘和喘息的关系：系统评价和荟萃分析。
Pediatr Allergy Immunol. 2012 Sep;23(6):509-18. doi: 10.1111/j.1399-3038.2012.01312.x. Epub 2012 May 25.
9
Protection from childhood asthma and allergy in Alpine farm environments-the GABRIEL Advanced Studies.阿尔卑斯农场环境中预防儿童哮喘和过敏——GABRIEL 高级研究。
J Allergy Clin Immunol. 2012 Jun;129(6):1470-7.e6. doi: 10.1016/j.jaci.2012.03.013. Epub 2012 Apr 24.
10
Exposure to environmental microorganisms and childhood asthma.暴露于环境微生物与儿童哮喘。
N Engl J Med. 2011 Feb 24;364(8):701-9. doi: 10.1056/NEJMoa1007302.