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提取物对氧化和炎症反应的抑制作用。

Inhibitory Effects of Extract on Oxidation and Inflammatory Responses.

作者信息

Lee Chul Won, Ahn Yong-Tae, Zhao Rongjie, Kim Youn Sook, Park Sang Mi, Jung Dae Hwa, Kim Jae Kwang, Kim Hyung Woo, Kim Sang Chan, An Won G

机构信息

Research Institute for Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

Department of Psychopharmacology, Qiqihar Medical University, Qiqihar 161006, China.

出版信息

Evid Based Complement Alternat Med. 2021 Apr 1;2021:6650037. doi: 10.1155/2021/6650037. eCollection 2021.

DOI:10.1155/2021/6650037
PMID:33868441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8034998/
Abstract

(laver) has long been a popular and traditional seaweed food in Korea, Japan, and China. Historically, it was known as a marine medicinal herb to treat hemorrhoids and cholera morbus in . We investigated the effects of extract (PTE) for its antioxidant and anti-inflammatory activities. These activities were measured using assays for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging and its superoxide dismutase- (SOD-) like activity, and through the inhibitory production of inflammatory mediators (prostaglandin E (PGE), NO, tumor necrosis factor alpha (TNF-), and interleukin-6 (IL-6)) in lipopolysaccharide- (LPS-) stimulated Raw 264.7 cells. The antioxidant assay results showed that PTE displayed DPPH radical scavenging activity (46.44%), NO radical scavenging activity (67.14%), and SOD-like activity (80.29%) at a concentration of 5 mg/mL. In the anti-inflammatory assays, treatment with PTE (1 mg/mL) significantly inhibited expression levels of LPS-induced COX-2 and iNOS, as well as the production of PGE, NO, TNF-, and IL-6. These results show that PTE has antioxidant and anti-inflammatory properties and provide scientific evidence to explain the antioxidative and anti-inflammatory properties of PTE.

摘要

紫菜在韩国、日本和中国长期以来一直是一种受欢迎的传统海藻类食品。历史上，它被视为一种海洋药草，用于治疗痔疮和霍乱。我们研究了紫菜提取物（PTE）的抗氧化和抗炎活性。这些活性通过2,2-二苯基-1-苦基肼（DPPH）和一氧化氮（NO）自由基清除测定及其超氧化物歧化酶（SOD）样活性来衡量，并通过在脂多糖（LPS）刺激的Raw 264.7细胞中抑制炎性介质（前列腺素E（PGE）、NO、肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6））的产生来评估。抗氧化测定结果表明，PTE在浓度为5 mg/mL时表现出DPPH自由基清除活性（46.44%）、NO自由基清除活性（67.14%）和SOD样活性（80.29%）。在抗炎测定中，用PTE（1 mg/mL）处理显著抑制了LPS诱导的COX-2和iNOS的表达水平，以及PGE、NO、TNF-α和IL-6的产生。这些结果表明PTE具有抗氧化和抗炎特性，并为解释PTE的抗氧化和抗炎特性提供了科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/f898e90e9513/ECAM2021-6650037.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/3caf23be5a2e/ECAM2021-6650037.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/bd8c33ac49d8/ECAM2021-6650037.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/ca952e41699d/ECAM2021-6650037.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/982718f10da1/ECAM2021-6650037.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/d5f826b3e203/ECAM2021-6650037.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/f898e90e9513/ECAM2021-6650037.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/3caf23be5a2e/ECAM2021-6650037.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/bd8c33ac49d8/ECAM2021-6650037.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/ca952e41699d/ECAM2021-6650037.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/982718f10da1/ECAM2021-6650037.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/d5f826b3e203/ECAM2021-6650037.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdbf/8034998/f898e90e9513/ECAM2021-6650037.006.jpg

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