Topoisomerase II as a target for repurposed antibiotics in : an in silico study.

Fluoroquinolines, the widely used antibacterial antibiotics, have been shown to interact with human DNA topoisomerases supporting their use as repurposed cancer drugs in humans. In this communication molecular docking of eleven Fluoroquinolines against predicted structure of Topoisomerase II is reported for the first time. topoisomerase II structure prediction was done by using homology modeling tool. Ligand preparation and molecular docking with topoisomerase II were done by using Autodock tool. These antibiotics formed hydrogen bond with good binding affinity at ARG 841, GLN803, ALA840 amino acid residues in the active site of Topoisomerase II. We hypothesize that DNA toposiomerases may be the targets of Fluroquinoline group of antibiotics in causing inhibition of growth.