Saavedra-Leos María Zenaida, Jordan-Alejandre Euclides, López-Camarillo César, Pozos-Guillen Amaury, Leyva-Porras César, Silva-Cázares Macrina Beatriz
Coordinación Académica Región Altiplano, Universidad Autónoma de San Luis Potosí, Matehuala, Mexico.
Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico City, Mexico.
Front Oncol. 2021 Apr 1;11:664380. doi: 10.3389/fonc.2021.664380. eCollection 2021.
Resveratrol and quercetin are natural compounds contained in many foods and beverages. Reports indicate implications for the health of the general population; on the other hand the use of both compounds has interesting results for the treatment of many diseases as cardiovascular affections, diabetes, Alzheimer's disease, viral and bacterial infections among others. Based on their capacities described as anti-inflammatory, antioxidant, and anti-aging, resveratrol and quercetin showed antiproliferative and anticancer activity specifically in maligned cells. These molecular characteristics trigger the pharmacological repurposing of both compounds and improved its research for treating different cancer types with interesting results at , and clinical trial studies. Meanwhile, the development of different systems of drug release in specific sites as nanomaterials and specifically the nanoparticles, potentiates the personal treatment perspective in conjunct with the actual cancer therapies; regularly invasive and aggressive, the perspective of nanomedicine as higher effective and lower invasive has gained popularity. Knowledge of molecular interactions of resveratrol and quercetin in diseases confirms the evidence of multiple benefits, while the multiple analyses suggested a positive response for the treatment and diagnostics of cancer in different stages, including at metastatic stage. The present work reviews the reports related to the impact of resveratrol and quercetin in cancer treatment and its effects when the antioxidants are encapsulated in different nanoparticle systems, which improve the prospects of cancer treatment.
白藜芦醇和槲皮素是许多食品和饮料中含有的天然化合物。报告显示它们对普通人群的健康有益；另一方面，这两种化合物在治疗许多疾病方面也有显著效果，如心血管疾病、糖尿病、阿尔茨海默病、病毒和细菌感染等。基于其抗炎、抗氧化和抗衰老的特性，白藜芦醇和槲皮素在恶性细胞中表现出抗增殖和抗癌活性。这些分子特性引发了对这两种化合物的药物重新利用，并加强了对其治疗不同癌症类型的研究，在临床试验研究中取得了有趣的结果。同时，作为纳米材料特别是纳米颗粒的特定部位药物释放系统的发展，结合实际的癌症治疗方法，增强了个性化治疗的前景；传统的癌症治疗方法通常具有侵入性和攻击性，而纳米医学具有更高的有效性和更低的侵入性，因此越来越受到关注。白藜芦醇和槲皮素在疾病中的分子相互作用知识证实了它们具有多种益处，同时多项分析表明它们对不同阶段癌症的治疗和诊断，包括转移阶段，都有积极反应。本研究综述了有关白藜芦醇和槲皮素在癌症治疗中的作用以及当抗氧化剂被包裹在不同纳米颗粒系统中时其效果的报告，这些研究改善了癌症治疗的前景。
