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Cytomegalovirus pneumonia in patients with inflammatory bowel disease: a systematic review.炎症性肠病患者巨细胞病毒肺炎：系统综述。
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Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis.克罗恩病、硫嘌呤类药物和原发性 EBV 感染与噬血细胞性淋巴组织细胞增生症的关联。
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一名患有克罗恩病的年轻女性硫嘌呤治疗的严重并发症

Severe Complication of Thiopurine Treatment in a Young Woman with Crohn's Disease.

作者信息

Voet Mpj, Calon Tga, Hendriks Mmc, Schreuder R M

机构信息

Department of Internal Medicine, Catharina Ziekenhuis, Eindhoven, The Netherlands.

Department of Gastroenterology and Hepatology, Catharina Ziekenhuis, Eindhoven, The Netherlands.

出版信息

Eur J Case Rep Intern Med. 2021 Mar 29;8(3):002350. doi: 10.12890/2021_002350. eCollection 2021.

DOI:10.12890/2021_002350
PMID:33869095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8046284/
Abstract

CASE DESCRIPTION

A 28-year old woman receiving thiopurine treatment for Crohn's disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis). Secondary to this systemic infection, she developed splenomegaly, pancytopenia and lymphadenopathy. Anti-viral treatment resulted in complete resolution of clinical, biochemical and radiological abnormalities within 6 weeks.

CONCLUSION

Early recognition is crucial since CMV infection in a patient receiving thiopurine treatment may result in serious complications.

LEARNING POINTS

Cytomegalovirus (CMV) infection in patients receiving thiopurine treatment may result in serious complications.This case report describes extensive primo CMV infection causing colitis, hepatitis, pneumonitis and retinitis in a patient receiving thiopurine treatment.Early recognition and treatment of the infection is crucial.

摘要

病例描述

一名28岁接受硫唑嘌呤治疗克罗恩病的女性患者出现全身性原发性巨细胞病毒（CMV）感染，累及肠道（结肠炎）、肝脏（肝炎）、肺部（肺炎）和眼睛（视网膜炎）。继发于这种全身性感染，她出现了脾肿大、全血细胞减少和淋巴结病。抗病毒治疗使临床、生化和影像学异常在6周内完全消退。

结论

早期识别至关重要，因为接受硫唑嘌呤治疗的患者发生CMV感染可能导致严重并发症。

学习要点

接受硫唑嘌呤治疗的患者发生巨细胞病毒（CMV）感染可能导致严重并发症。本病例报告描述了一名接受硫唑嘌呤治疗的患者发生广泛的原发性CMV感染，导致结肠炎、肝炎、肺炎和视网膜炎。对该感染的早期识别和治疗至关重要。