Xin Yanguo, Li Junli, Wu Wenchao, Liu Xiaojing
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.
Front Cell Dev Biol. 2021 Apr 1;9:647631. doi: 10.3389/fcell.2021.647631. eCollection 2021.
Cell proliferation is an important cellular process for physiological tissue homeostasis and remodeling. The mechanisms of cell proliferation in response to pathological stresses are not fully understood. Mitochondria are highly dynamic organelles whose shape, number, and biological functions are modulated by mitochondrial dynamics, including fusion and fission. Mitofusin-2 (Mfn-2) is an essential GTPase-related mitochondrial dynamics protein for maintaining mitochondrial network and bioenergetics. A growing body of evidence indicates that Mfn-2 has a potential role in regulating cell proliferation in various cell types. Here we review these new functions of Mfn-2, highlighting its crucial role in several signaling pathways during the process of pathological cell proliferation. We conclude that Mfn-2 could be a new mediator of pathological cell proliferation and a potential therapeutic target.
细胞增殖是维持生理组织稳态和重塑的重要细胞过程。目前对细胞在病理应激下增殖的机制尚未完全了解。线粒体是高度动态的细胞器，其形状、数量和生物学功能受线粒体动力学（包括融合和裂变）的调节。线粒体融合蛋白2（Mfn-2）是一种与GTP酶相关的重要线粒体动力学蛋白，对维持线粒体网络和生物能量学至关重要。越来越多的证据表明，Mfn-2在调节多种细胞类型的细胞增殖中具有潜在作用。在此，我们综述Mfn-2的这些新功能，强调其在病理性细胞增殖过程中若干信号通路中的关键作用。我们得出结论，Mfn-2可能是病理性细胞增殖的新介质和潜在的治疗靶点。
