Neurology-Stroke Unit, AO Ospedale Civile di Legnano, ASST Ovest Milanese, Legnano, Italy.
Neurology Unit, Department of Clinical and Experimental Medicine University of Pisa, Italy.
Acta Myol. 2021 Mar 31;40(1):1-7. doi: 10.36185/2532-1900-040. eCollection 2021 Mar.
To investigate both muscular manifestations and CK levels in a large cohort of patients with COVID-19 infection and to determine whether hyperckemia is associated with morbidity and mortality.
Data of 615 patients discharged from ASST Ovest Milanese (Milan, Lombardy, Italy) with final diagnosis of COVID-19 infection were retrospectively extracted from electronical medical records from 21 February to 1 May 2020. Patients were descriptively analyzed with respect to the following variables: sex, age, muscular manifestations (myalgia and/or arthralgia), fatigue, respiratory involvement (SARS pneumonia or respiratory failure) and history of falls. Association between patients' characteristics and CK levels was investigated. In addition, the proportion of patients who died following access to the ER was calculated. Finally, the effect of CK levels and other patients' features on mortality was estimated using a logistic regression model.
176 (28.6%) patients had raised serum CK levels. CK levels were significantly associated with history of falls, male gender, SARS pneumonia, respiratory failure and in-hospital death. No correlation was found between hyperckemia and muscular manifestations.
Our study provides preliminary evidence that hyperckemia is associated with respiratory failure and fatal outcome in patients with COVID-19 infection.In these patients, among other testing, CK dosage is recommended.
研究大量 COVID-19 感染患者的肌肉表现和 CK 水平，并确定高 CK 是否与发病率和死亡率相关。
从 2020 年 2 月 21 日至 5 月 1 日从电子病历中回顾性提取了来自 ASST Ovest Milanese（意大利伦巴第大区米兰）的 615 名出院的 COVID-19 感染患者的数据。患者根据以下变量进行描述性分析：性别、年龄、肌肉表现（肌痛和/或关节痛）、疲劳、呼吸受累（SARS 肺炎或呼吸衰竭）和跌倒史。研究了患者特征与 CK 水平之间的关系。此外，计算了进入急诊室后死亡的患者比例。最后，使用逻辑回归模型估计 CK 水平和其他患者特征对死亡率的影响。
176 名（28.6%）患者的血清 CK 水平升高。CK 水平与跌倒史、男性、SARS 肺炎、呼吸衰竭和院内死亡显著相关。高 CK 血症与肌肉表现之间无相关性。
我们的研究提供了初步证据，表明 COVID-19 感染患者的高 CK 血症与呼吸衰竭和致命结局相关。在这些患者中，建议除其他检查外，还应进行 CK 检测。
