Donovitz Gary, Cotten Mandy
Morehouse College of Medicine, Atlanta, Georgia, USA.
BioTE Medical, LLC, Irving, Texas, USA.
Eur J Breast Health. 2021 Mar 31;17(2):150-156. doi: 10.4274/ejbh.galenos.2021.6213. eCollection 2021 Apr.
Testosterone (T) therapy has been shown to be breast protective in both pre- and post-menopausal patients. Additionally, estradiol (E) does not cause breast cancer (BC) in the majority of the world's literatures. This study aimed to investigate the incidence of invasive BC (IBC) in pre- and postmenopausal women treated with T therapy and T in combination with E (T/E).
Since January 2010, a total of 2,377 pre- and post-menopausal women were treated with T or T/E implants. IBC rates were reported based on newly diagnosed IBC cases in the total study. Total cases divided by the total sample size and years in study was expressed as an incidence per 100,000 person-years (P-Ys). The BC incidence was compared with age-specific Surveillance Epidemiology and End Results (SEER) incidence rates.
As of October 2020, 14 cases diagnosed with IBC have been found in 9,746 P-Y of follow up for an incidence of 144 cases per 100,000 P-Y, substantially less than the age-specific SEER incidence rates (223/100,000), placebo arm of Women's Health Initiative Study (330/100,000), and never users of hormone therapy from the Million Women Study (312/100,000).
T and/or T/E pellet implants significantly reduced the incidence of BC in pre- and post-menopausal women. The addition of E did not increase the incidence over using T alone. This is the second multi-year long-term study demonstrating the benefits of T therapy in reducing the incidence of IBC.
睾酮（T）疗法已被证明对绝经前和绝经后患者均有乳腺保护作用。此外，在世界上大多数文献中，雌二醇（E）不会引发乳腺癌（BC）。本研究旨在调查接受T疗法以及T与E联合疗法（T/E）的绝经前和绝经后女性中浸润性乳腺癌（IBC）的发病率。
自2010年1月起，共有2377名绝经前和绝经后女性接受了T或T/E植入治疗。IBC发病率是根据整个研究中新诊断出的IBC病例报告的。总病例数除以总样本量和研究年限，以每10万人年（P-Ys）的发病率表示。将BC发病率与特定年龄的监测、流行病学和最终结果（SEER）发病率进行比较。
截至2020年10月，在9746人年的随访中发现了14例诊断为IBC的病例，发病率为每10万人年144例，显著低于特定年龄的SEER发病率（223/10万）、妇女健康倡议研究的安慰剂组（330/10万）以及百万女性研究中从未使用过激素疗法的人群（312/10万）。
T和/或T/E颗粒植入显著降低了绝经前和绝经后女性的BC发病率。添加E并未使发病率高于单独使用T时的发病率。这是第二项为期多年的长期研究，证明了T疗法在降低IBC发病率方面的益处。
