West Boca Center for Wound Healing, Coconut Creek, Florida.
Surgical Services, Berger Health System, Circleville, Ohio.
Wounds. 2021 Jul;33(7):169-177. doi: 10.25270/wnds/2021.169177. Epub 2021 Apr 14.
Omega-3-rich fish skin grafts have been shown to accelerate wound healing in full-thickness wounds.
The goal of this study was to compare the fish skin graft with standard of care (SOC) using collagen alginate dressing in the management of treatment-resistant diabetic foot ulcers (DFUs), defined as superficial ulcers not involving tendon capsule or bone.
Patients with DFUs who were first treated with SOC (offloading, appropriate debridement, and moist wound care) for a 2-week screening period were then randomized to either receiving SOC alone or SOC plus fish skin graft applied weekly for up to 12 weeks. The primary endpoint was the percentage of wounds closed at 12 weeks.
Forty-nine patients were included in the final analysis. At 12 weeks, 16 of 24 patients' DFUs (67%) in the fish skin arm were completely closed, compared with 8 of 25 patients' DFUs (32%) in the SOC arm (P value = .0152 [N = 49]; significant at P < .047). At 6 weeks, the percentage area reduction was 41.2% in the SOC arm and 72.8% in the fish skin arm.
The application of fish skin graft to previously nonresponsive DFUs resulted in significantly more fully healed wounds at 12 weeks than SOC alone. The study findings support the use of fish skin graft for chronic DFUs that do not heal with comprehensive SOC treatment.
富含欧米伽-3 的鱼皮移植物已被证明可加速全层伤口的愈合。
本研究的目的是比较鱼皮移植物与标准治疗（SOC），使用藻酸钙胶原敷料在治疗抵抗性糖尿病足溃疡（DFU）的管理，定义为不涉及肌腱囊或骨的浅表溃疡。
DFU 患者首先接受 SOC（减压、适当清创和湿性伤口护理）进行为期 2 周的筛选期，然后随机分为 SOC 单独治疗或 SOC 加每周应用鱼皮移植物治疗，最多 12 周。主要终点是 12 周时伤口闭合的百分比。
49 例患者最终纳入分析。在 12 周时，鱼皮组 24 例患者中有 16 例（67%）DFU 完全闭合，SOC 组 25 例患者中有 8 例（32%）DFU 完全闭合（P 值=.0152 [N = 49]；P <.047）。在 6 周时，SOC 组的面积减少百分比为 41.2%，鱼皮组为 72.8%。
将鱼皮移植物应用于先前对 SOC 无反应的 DFU，在 12 周时导致更多的完全愈合的伤口，比 SOC 单独治疗效果更好。研究结果支持使用鱼皮移植物治疗慢性 DFU，这些 DFU 不能通过全面的 SOC 治疗愈合。
