Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Gastrointestinal Surgery Department II, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Mitochondrion. 2021 Jul;59:123-134. doi: 10.1016/j.mito.2021.04.001. Epub 2021 Apr 17.
Colorectal cancer (CRC) affects millions of people worldwide. Chemoresistance seriously impairs the therapeutic effects. Lipid droplets (LDs) abnormally accumulate in CRC supported chemoresistance. Exploring the mechanism of LD-induced chemoresistance is extremely important for improving prognosis of CRC patients. The expression of PTMA was increased in both CRC tissues and cells, which was positively correlated with LD production. PTMA facilitated chemoresistance to gemcitabine by inducing LD production in CRC cells. PTMA enhanced LD biogenesis and chemoresistance to gemcitabine by promoting SREBP-1-mediated lipogenesis and STAT3 activation in CRC.
结直肠癌（CRC）影响着全球数以百万计的人群。化疗耐药严重影响了治疗效果。脂滴（LDs）在支持 CRC 化疗耐药的过程中异常积累。探索 LD 诱导的化疗耐药的机制对于改善 CRC 患者的预后极为重要。PTMA 在 CRC 组织和细胞中的表达均增加，与 LD 产生呈正相关。PTMA 通过诱导 CRC 细胞中 LD 的产生促进了吉西他滨的化疗耐药性。PTMA 通过促进 SREBP-1 介导的脂肪生成和 STAT3 激活，增强了 LD 的生物发生和对吉西他滨的化疗耐药性。
