Lee Yeon Jung, Park Seo Young, Sung Lee Yun, Kim Jung Ho, Choi Jongkwan, Oh Kyounghee, Hahn Sang-Woo
Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul, Republic of Korea.
Department of Medical Sciences, Graduate School of Soonchunhyang University, Asan, Republic of Korea.
Psychiatry Res Neuroimaging. 2021 Jun 30;312:111288. doi: 10.1016/j.pscychresns.2021.111288. Epub 2021 Apr 10.
The reduction in the oxygenation dynamics in the prefrontal cortex (PFC) during cognitive tasks is a well-known occurrence in major depressive disorders (MDD). Studies focusing on oxygenation changes in the PFC in individuals with suicidal ideation are limited. Therefore, this study investigated and confirmed the presence of prefrontal dysfunction depending on the intensity of suicidal ideation among 77 young adults (45 patients with MDD and 32 healthy controls) using near-infrared spectroscopy (NIRS). All participants underwent assessment with the Beck Depression Inventory-II, Beck Anxiety Inventory, and Beck Scale for Suicidal ideation. NIRS revealed relative hypofunction in the left dorsolateral PFC, left ventrolateral PFC (LVLPFC), and both orbitofrontal cortices in young adults with MDD compared to that in the healthy controls during verbal fluency tasks. Furthermore, the oxyhaemoglobin changes in the LVLPFC mediated the indirect effect of depression severity on suicidal ideation intensity. Our results confirmed that functional NIRS is a useful auxiliary tool for objectively assessing the risk of suicidal ideation.
在认知任务期间前额叶皮质（PFC）的氧合动力学降低是重度抑郁症（MDD）中一种众所周知的现象。针对有自杀意念个体的PFC氧合变化的研究有限。因此，本研究使用近红外光谱（NIRS），在77名年轻人（45名MDD患者和32名健康对照）中，根据自杀意念的强度调查并证实了前额叶功能障碍的存在。所有参与者均接受了贝克抑郁量表第二版、贝克焦虑量表和贝克自杀意念量表的评估。近红外光谱显示，在言语流畅性任务期间，与健康对照相比，MDD年轻成年人的左侧背外侧前额叶皮质、左侧腹外侧前额叶皮质（LVLPFC）以及双侧眶额叶皮质存在相对功能减退。此外，LVLPFC中的氧合血红蛋白变化介导了抑郁严重程度对自杀意念强度的间接影响。我们的结果证实，功能性近红外光谱是客观评估自杀意念风险的有用辅助工具。
