Department of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama, 3500495, Japan.
Sci Rep. 2022 Oct 17;12(1):17377. doi: 10.1038/s41598-022-22345-3.
Suicide is a serious public health problem, and it is urgent to identify biomarkers associated with suicide to prevent it. We aimed to clarify the association across suicidal behavior, personality traits, and brain activation by emotional stimulation tasks using near-infrared spectroscopy (NIRS) in patients with mood disorders. 11 mood disorder patients with a history of suicide attempt (MDSA), 18 mood disorder patients with no history of suicide attempt (MDNSA), and 17 healthy individuals were studied. The MDSA patients showed significantly high impulsivity and hopeless compared to healthy subjects, great response to the thread word task in the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) compared to MDNSA patients, and the significant correlation between the personality traits and brain activation. The MDNSA did not show the trend. The results suggest that the personality traits and the activation of OFC and DLPFC during the negative emotional cognitive stimuli is associated with suicidal behavior, indicating the findings are involved in the pathophysiology of suicidality in mood disorders.
自杀是一个严重的公共卫生问题，迫切需要确定与自杀相关的生物标志物，以预防自杀。我们旨在通过情绪刺激任务使用近红外光谱（NIRS）阐明心境障碍患者的自杀行为、人格特质和大脑激活之间的关联。研究了 11 名有自杀未遂史的心境障碍患者（MDSA）、18 名无自杀未遂史的心境障碍患者（MDNSA）和 17 名健康个体。与健康受试者相比，MDSA 患者表现出明显更高的冲动性和绝望感，与 MDNSA 患者相比，在眶额皮层（OFC）和背外侧前额叶皮层（DLPFC）对威胁词任务的反应更大，并且人格特质和大脑激活之间存在显著相关性。MDNSA 没有表现出这种趋势。研究结果表明，负性情绪认知刺激期间的人格特质和 OFC 及 DLPFC 的激活与自杀行为相关，表明这些发现与心境障碍患者自杀行为的病理生理学有关。
