Wee B E, Weaver D R, Clemens L G
Department of Zoology, Michigan State University, East Lansing 48824.
Physiol Behav. 1988;42(1):77-82. doi: 10.1016/0031-9384(88)90263-6.
In contrast to the facilitative effects reported for other rodents, testosterone treatment at the time of castration previously was reported to inhibit masculine sexual behavior in male B6D2F1 mice. Males of this genotype vary in their behavioral response to castration. Some castrates retain sexual behaviors for many weeks after surgery, whereas others do not. In the present study, we sought to determine the effects of exogenous steroid hormone treatment on castrated B6D2F1 mice that had ceased to show copulatory behavior. Testosterone propionate and estradiol benzoate restored copulatory behavior to precastration levels in B6D2F1 males that did not retain sexual behaviors after castration.
与其他啮齿动物所报道的促进作用相反，先前有报道称，在去势时进行睾酮处理会抑制雄性B6D2F1小鼠的雄性性行为。这种基因型的雄性对去势的行为反应存在差异。一些去势小鼠在手术后数周仍保留性行为，而另一些则不然。在本研究中，我们试图确定外源性类固醇激素处理对已停止表现出交配行为的去势B6D2F1小鼠的影响。丙酸睾酮和苯甲酸雌二醇可使去势后未保留性行为的B6D2F1雄性小鼠的交配行为恢复到去势前水平。
