Clemens L G, Wee B E, Weaver D R, Roy E J, Goldman B D, Rakerd B
Department of Zoology, Michigan State University, East Lansing 48824.
Physiol Behav. 1988;42(1):69-76. doi: 10.1016/0031-9384(88)90262-4.
The reduction of masculine sexual behavior following castration varies widely among genotypes. In contrast to the loss of sexual behavior by castrated males of other strains, males of the B6D2F1 genotype retain the ejaculatory reflex for many weeks after castration. The present study examined this retention phenomenon. Masculine sexual behaviors were measured before and after castration or sham operation in male C57BL/6J, DBA/2J, and B6D2F1 mice. Castrated C57BL/6J and DBA/2J males showed a rapid decline in copulatory behavior. In contrast, 30% of the B6D2F1 males continued to ejaculate 25 weeks after castration. Regardless of whether or not sexual behaviors were retained, levels of plasma testosterone and hypothalamic nuclear estrogen receptors were reduced by castration. These results suggest that the intra- and inter-strain differences in the retention of sexual behavior following castration are not due to differences in levels of steroid hormones. Further, some B6D2F1 males retain the ability to copulate in the absence of gonadal hormone levels required for the maintenance of sexual behavior in other genotypes.
阉割后雄性性行为的减少在不同基因型之间差异很大。与其他品系阉割雄性的性行为丧失不同，B6D2F1基因型的雄性在阉割后数周仍保留射精反射。本研究对这种保留现象进行了研究。在雄性C57BL/6J、DBA/2J和B6D2F1小鼠阉割或假手术前后测量其雄性性行为。阉割后的C57BL/6J和DBA/2J雄性的交配行为迅速下降。相比之下，30%的B6D2F1雄性在阉割后25周仍继续射精。无论性行为是否保留，阉割都会降低血浆睾酮水平和下丘脑核雌激素受体水平。这些结果表明，阉割后性行为保留的品系内和品系间差异并非由于类固醇激素水平的差异。此外，一些B6D2F1雄性在缺乏维持其他基因型性行为所需的性腺激素水平的情况下仍保留交配能力。
