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针对可能的癌症症状进行全科医生会诊的定向鼓励:一项随机对照试验。

Targeted encouragement of GP consultations for possible cancer symptoms: a randomised controlled trial.

作者信息

Laake Jean-Pierre, Vulkan Daniel, Quaife Samantha L, Hamilton William T, Martins Tanimola, Waller Jo, Parmar Dharmishta, Sasieni Peter, Duffy Stephen W

机构信息

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London; medical student, Warwick Medical School, University of Warwick, Coventry.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London.

出版信息

Br J Gen Pract. 2021 Apr 29;71(706):e339-e346. doi: 10.3399/bjgp20X713489. Print 2021 May.

Abstract

BACKGROUND

For some common cancers, survival is lower in the UK than in comparable high-income countries.

AIM

To assess the effectiveness of a targeted postal intervention (to promote awareness of cancer symptoms and earlier help seeking) on patient consultation rates.

DESIGN AND SETTING

A two-arm randomised controlled trial was carried out on patients aged 50-84 years registered at 23 general practices in rural and urban areas of Greater London, Greater Manchester, and the North East of England.

METHOD

Patients who had not had a consultation at their general practice in the previous 12 months and had at least two other risk factors for late presentation with cancer were randomised to intervention and control arms. The intervention consisted of a posted letter and leaflet. Primary outcome was the number of consultations at the practice with patients randomised to each arm in the 6 months subsequent to posting the intervention. All patients with outcome data were included in the intention-to-treat analyses.

RESULTS

In total, 1513 patients were individually randomised to the intervention ( = 783) and control ( = 730) arms between Nov 2016 - May 2017; outcome data were available for 749 and 705 patients, respectively, with a statistically significantly higher rate of consultation in the intervention arm compared with the control arm: 436 versus 335 consultations (relative risk 1.40, 95% confidence interval = 1.11 to 1.77, = 0.004). There was, however, no difference in the numbers of patients consulting.

CONCLUSION

Targeted interventions of this nature can change behaviour; there is a need to develop interventions that can be more effective at engaging patients with primary care. This study demonstrates that targeted interventions promoting both awareness of possible cancer symptoms and earlier health seeking, can change behaviour. There is a need to develop and test interventions that can be more effective at engaging the most at-risk patients.

摘要

背景

对于一些常见癌症,英国患者的生存率低于其他可比的高收入国家。

目的

评估有针对性的邮政干预措施(提高对癌症症状的认识并鼓励更早寻求帮助)对患者就诊率的有效性。

设计与地点

在大伦敦、大曼彻斯特和英格兰东北部城乡地区的23家全科诊所登记的50 - 84岁患者中进行了一项双臂随机对照试验。

方法

在过去12个月内未在其全科诊所就诊且至少有另外两个癌症延迟就诊风险因素的患者被随机分为干预组和对照组。干预措施包括一封邮寄信件和一份传单。主要结局是在寄出干预措施后的6个月内,随机分配到每组的患者在诊所的就诊次数。所有有结局数据的患者都纳入意向性分析。

结果

2016年11月至2017年5月期间,共有1513名患者被分别随机分配到干预组(n = 783)和对照组(n = 730);分别有749名和705名患者获得了结局数据,干预组的就诊率在统计学上显著高于对照组:436次就诊与335次就诊(相对风险1.40,95%置信区间 = 1.11至1.77,P = 0.004)。然而,就诊患者的数量没有差异。

结论

这种有针对性的干预措施可以改变行为;需要开发更有效的干预措施,以促使患者参与初级保健。本研究表明,促进对可能的癌症症状的认识和更早寻求医疗服务的有针对性干预措施可以改变行为。需要开发和测试能更有效地促使风险最高的患者参与的干预措施。

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