Hendawy Hamdy A, Mosallam Walid, Abuelnaga Mohamed E, Sabry Amr M
Faculty of Medicine, Suez Canal University, P.O. Box: 41522, The ring road, Ismailia City, Egypt.
SN Compr Clin Med. 2021;3(6):1424-1427. doi: 10.1007/s42399-021-00895-3. Epub 2021 Apr 14.
COVID-19 is a newly discovered deadly disease with no proven definitive treatment until now. It is now proved that it can affect different body organs which necessitate intensive care management. Ozone (O3) therapy was used before for treating various viral infections like hepatitis B, human immune deficiency virus (HIV), and Ebola viruses. O3 also can manage hypoxia and increase tissue oxygenation, besides its anti-inflammatory and immunomodulatory properties which may have an important role in the management of cytokine storm. We used rectal O3 insufflation therapy assuming that it may have a beneficial role in the management of COVID-19 disease. Two sessions of rectal O3 therapy were given to a 60-year-old female patient who was confirmed COVID-19 positive. Before applying O3 therapy, she was hypoxic (sPO2:90%) despite mechanical ventilation with high fraction inspired oxygen (FiO2:90%). After therapy, she was markedly improved and discharged to the inpatient ward and then discharged home on day 10 post-admission. Another 40-year-old male patient who was confirmed COVID-19 positive and was home isolated received one session of O3 therapy. Before therapy, he was hypoxic (sPO2:85% on room air and 95% with O2 face mask 5 L/min). The patient showed gradual improvement over the next 3 days after therapy and becomes oxygen-independent (sPO2 became 94-97% on room air). No adverse effects were noticed in both cases. Rectal O3 insufflation can be used safely as adjuvant management for patients with COVID-19 disease.
新型冠状病毒肺炎（COVID-19）是一种新发现的致命疾病，迄今为止尚无经证实的明确治疗方法。现已证明，它可影响不同身体器官，因此需要重症监护管理。臭氧（O3）疗法以前曾用于治疗各种病毒感染，如乙型肝炎、人类免疫缺陷病毒（HIV）和埃博拉病毒。O3还可以处理缺氧情况并增加组织氧合，此外其抗炎和免疫调节特性可能在细胞因子风暴的管理中发挥重要作用。我们采用直肠臭氧注入疗法，认为其可能在COVID-19疾病的管理中发挥有益作用。对一名确诊为COVID-19阳性的60岁女性患者进行了两疗程的直肠臭氧疗法。在应用臭氧疗法之前，尽管采用高浓度吸氧（FiO2：90%）进行机械通气，她仍存在缺氧（经皮血氧饱和度：90%）。治疗后，她明显好转，转至住院病房，入院第10天出院回家。另一名确诊为COVID-19阳性且居家隔离的40岁男性患者接受了一疗程的臭氧疗法。治疗前，他存在缺氧（室内空气下经皮血氧饱和度：85%，佩戴5L/min氧气面罩时为95%）。治疗后，该患者在接下来的3天里逐渐好转，不再依赖氧气（室内空气下经皮血氧饱和度变为94%-97%）。两例均未观察到不良反应。直肠臭氧注入可安全地用作COVID-19疾病患者的辅助治疗。
