3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.
J Mater Chem B. 2021 May 12;9(18):3778-3799. doi: 10.1039/d1tb00233c.
Spin-coating is a widely employed technique for the fabrication of thin-film coatings over large areas with smooth and homogeneous surfaces. In recent years, research has extended the scope of spin-coating by developing methods involving the interface of the substrate and the deposited solution to obtain self-supported films, also called freestanding films. Thereby, such structures have been developed for a wide range of areas. Biomedical applications of spin-coated freestanding films include wound dressings, drug delivery, and biosensing. This review will discuss the fundamental physical and chemical processes governing the conventional spin-coating as well as the techniques to obtain freestanding films. Furthermore, developments within this field with a primary focus on tissue engineering applications will be reviewed.
旋涂是一种广泛应用的技术，用于在大面积上制造具有光滑和均匀表面的薄膜涂层。近年来，通过开发涉及基底和沉积溶液界面的方法，研究已经扩展了旋涂的范围，以获得自支撑膜，也称为自由站立膜。因此，已经为广泛的领域开发了这种结构。旋涂自由站立膜在生物医学中的应用包括伤口敷料、药物输送和生物传感。本文将讨论控制传统旋涂的基本物理和化学过程以及获得自由站立膜的技术。此外，还将回顾该领域的发展，主要关注组织工程应用。
