School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.
College of Food Science, Sichuan Agricultural University, No. 46, Xin Kang Road, Yaan, Sichuan Province 625014, China.
Carbohydr Polym. 2021 Nov 1;271:118427. doi: 10.1016/j.carbpol.2021.118427. Epub 2021 Jul 12.
In recent years, chitosan-based biomaterials have been continually and extensively researched by using layer-by-layer (LBL) assembly, due to their potentials in biomedicine. Various chitosan-based LBL materials have been newly developed and applied in different areas along with the development of technologies. This work reviews the recent advances of chitosan-based biomaterials produced by LBL assembly. Driving forces of LBL, for example electrostatic interactions, hydrogen bond as well as Schiff base linkage have been discussed. Various forms of chitosan-based LBL materials such as films/coatings, capsules and fibers have been reviewed. The applications of these biomaterials in the field of antimicrobial applications, drug delivery, wound dressings and tissue engineering have been comprehensively reviewed.
近年来，由于壳聚糖基生物材料在生物医学方面的潜力，利用层层（LBL）组装技术对其进行了持续广泛的研究。随着技术的发展，各种新型的壳聚糖基 LBL 材料已经被开发出来并应用于不同领域。本工作综述了通过 LBL 组装制备壳聚糖基生物材料的最新进展。讨论了 LBL 的驱动力，例如静电相互作用、氢键以及席夫碱键合。综述了各种形式的壳聚糖基 LBL 材料，如薄膜/涂层、胶囊和纤维。还全面综述了这些生物材料在抗菌应用、药物输送、伤口敷料和组织工程领域的应用。
