Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo,, 060-8638, Japan.
Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Fukuoka, Japan.
Graefes Arch Clin Exp Ophthalmol. 2021 Oct;259(10):2967-2976. doi: 10.1007/s00417-021-05198-w. Epub 2021 Apr 19.
To evaluate the clinical characteristics of patients with acute zonal occult outer retinopathy (AZOOR), according to the presence or absence of anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy.
Retrospective observational case series. This study included 33 patients with acute-stage AZOOR who had been followed up for more than 6 months after the initial visit. The median follow-up period was 26 months. Immunoblot analyses were used to detect autoantibodies for recoverin, carbonic anhydrase II, and α-enolase in serum from these patients. Main outcome measures comprised clinical factors at the initial and final visits, including best-corrected visual acuity, mean deviation on Humphrey perimetry, and retinal morphology, which were statistically compared between patients with AZOOR who exhibited ARAs and those who did not.
At least one serum ARA was detected in 42% of patients with AZOOR. There were no significant differences in clinical factors between the two groups, including follow-up period, best-corrected visual acuity and mean deviation at the initial and final visits, a-wave amplitude on single-flash electroretinography at the initial visit, and frequencies of improvement of the macular ellipsoid zone and AZOOR recurrence.
Our findings suggest that the presence of ARAs did not influence visual outcomes or outer retinal morphology in patients with AZOOR.
根据是否存在常与自身免疫性视网膜炎相关的抗视网膜抗体（ARAs），评估急性区域性隐匿性外层视网膜病变（AZOOR）患者的临床特征。
回顾性观察性病例系列研究。本研究纳入了 33 例急性 AZOOR 患者，这些患者在初次就诊后接受了超过 6 个月的随访。中位随访时间为 26 个月。采用免疫印迹分析检测这些患者血清中的抗 recoverin、碳酸酐酶 II 和 α-烯醇化酶抗体。主要观察指标包括初次就诊和末次就诊时的临床因素，包括最佳矫正视力、Humphrey 视野计平均偏差和视网膜形态，比较 AZOOR 患者中存在和不存在 ARAs 的两组之间的差异。
42%的 AZOOR 患者至少检测到一种血清 ARA。两组之间的临床因素无显著差异，包括随访时间、初次和末次就诊时的最佳矫正视力和平均偏差、初次就诊时单闪光视网膜电图的 a 波振幅以及黄斑椭圆区改善和 AZOOR 复发的频率。
我们的研究结果表明，ARAs 的存在并未影响 AZOOR 患者的视力预后或外层视网膜形态。
