State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, 100730, China.
Adv Mater. 2021 May;33(21):e2100595. doi: 10.1002/adma.202100595. Epub 2021 Apr 19.
Pancreatic cancer, one of the most lethal malignancies, compromises the performance of traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a biocompatible therapeutic paradigm that can effectively inhibit pancreatic tumor growth while simultaneously eliminating tumor metastasis is urgently needed. Herein, supramolecular nanofibrils are fabricated through coassembly of clinically approved immunomodulatory thymopentin and near-infrared indocyanine green for localized photothermal immunotherapy of pancreatic tumors. The resulting long-range ordered fibrous nanodrugs show improved photophysical capabilities for fluorescence imaging and photothermal conversion and significantly promote the proliferation and differentiation of antitumor immune cells. Hence, the integration of rapid photothermal therapy and moderate immunomodulation for inhibiting tumor growth and eliminating tumor metastasis is promising. The utilization of clinically approved molecules to construct nanodrugs administered via localized injection amplifies the complementary photothermal immunotherapeutic effects of the components, creating opportunities for clinical translation as a treatment for pancreatic cancer.
胰腺癌是最致命的恶性肿瘤之一，由于基质对全身药物输送的耐药性以及肿瘤转移导致的预后不良，临床上传统的治疗方案受到了影响。因此，迫切需要一种生物相容性的治疗范式，既能有效地抑制胰腺肿瘤生长，又能同时消除肿瘤转移。在这里，通过临床批准的免疫调节胸腺五肽和近红外吲哚菁绿的共组装，构建了超分子纳米纤维，用于胰腺肿瘤的局部光热免疫治疗。所得的长程有序纤维纳米药物显示出改进的荧光成像和光热转换的光物理性能，并显著促进抗肿瘤免疫细胞的增殖和分化。因此，快速光热治疗与适度免疫调节的结合有望抑制肿瘤生长和消除肿瘤转移。利用临床批准的分子构建局部注射给药的纳米药物，放大了成分的互补光热免疫治疗效果，为作为胰腺癌治疗的临床转化创造了机会。
