Montesissa C, Carli S, Sonzogni O, Garlappi R
Institute of Veterinary Pharmacology, Toxicology and Experimental Therapy, University of Milan, Italy.
Res Vet Sci. 1988 Mar;44(2):233-6.
The pharmacokinetics of sodium amoxicillin were investigated after intravenous and intramuscular administration of a single dose of 15 mg kg-1 body-weight to five horses. A rapid distribution phase was noted after intravenous administration (t1/2 alpha about 20 minutes). The t1/2 beta values obtained after the intravenous and the intramuscular administration were significantly different (P less than 0.05). The bioavailability obtained was about 67 per cent. Plasma protein binding, evaluated in vitro, showed that the percentage of bound fraction was 37 to 38 per cent. It was concluded that sodium amoxicillin administration at 15 mg kg-1 four times a day should be effective in the treatment of several systemic infections in the horse.
对5匹马静脉注射和肌肉注射单剂量15毫克/千克体重的阿莫西林钠后，研究了其药代动力学。静脉注射后出现快速分布相（t1/2α约20分钟）。静脉注射和肌肉注射后获得的t1/2β值有显著差异（P小于0.05）。获得的生物利用度约为67%。体外评估的血浆蛋白结合显示，结合部分的百分比为37%至38%。得出的结论是，每天4次以15毫克/千克的剂量给予阿莫西林钠应能有效治疗马的几种全身感染。
