Department of Hypertension, The First Affiliated Hospital of Xinjiang Medical University, Urumqi,Xinjiang, China.
Department of General Practice, Hetian Region People's Hospital, Hetian,Xinjiang, China.
Clin Exp Hypertens. 2021 Jul 4;43(5):443-449. doi: 10.1080/10641963.2021.1901107. Epub 2021 Apr 20.
To investigate the correlation between transient receptor potential channel 1 () gene polymorphism and microalbuminuria in patients with primary hypertension. : A total of 468 patients with primary hypertension were admitted to the Department of Hypertension of the First Affiliated Hospital of Xinjiang Medical University from April 2015 to November 2017. According to microalbuminuria, the patients were divided into two groups: high urinary albumin group (EH+mALB group, n = 71) and normal urinary microalbuminuria group (EH group, n = 397). The Sequenom detection technology was used for genotyping the single nucleotide polymorphism (SNP) sites of the gene, such as rs1382688, rs3821647, rs7638459, rs953239, and rs7621642.
(1) No significant differences were detected in gender, smoking history, drinking history, family history, course of hypertension, fasting blood glucose, urea, creatinine, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glycosylated hemoglobin, vitamin D, homocysteine, and cystatin C between the two groups ( > .05). However, age, body mass index (BMI), 24-h mean systolic and diastolic blood pressure, and 24-h average pulse pressure were statistically significant ( < .05). (2) No significant difference was detected in the distribution frequency of the polymorphisms of the gene between the two groups ( > .05), while the genotype, allele, and recessive model of rs7638459 differed significantly difference ( < .05). (3) Logistic regression analysis showed that BMI and rs7638459 CC genotype were the risk factors of increased microalbuminuria in patients with primary hypertension.
gene polymorphism is associated with increased microalbuminuria in patients with primary hypertension. The CC genotype of rs7638459 may increase the risk of microalbuminuria in patients with essential hypertension, while BMI and rs7638459 CC genotype may be the risk factors of increased microalbuminuria in patients with primary hypertension.
探讨瞬时受体电位通道 1（TRPC1）基因多态性与原发性高血压患者微量白蛋白尿的相关性。方法：选取 2015 年 4 月至 2017 年 11 月新疆医科大学第一附属医院高血压科收治的 468 例原发性高血压患者，根据微量白蛋白尿将患者分为两组：高尿白蛋白组（EH+mALB 组，n=71）和正常尿微量白蛋白组（EH 组，n=397）。采用 Sequenom 检测技术对基因 rs1382688、rs3821647、rs7638459、rs953239、rs7621642 等单核苷酸多态性（SNP）位点进行基因分型。结果：（1）两组患者的性别、吸烟史、饮酒史、家族史、高血压病程、空腹血糖、尿素、肌酐、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、维生素 D、同型半胱氨酸、胱抑素 C 比较，差异均无统计学意义（>0.05）；年龄、体质量指数（BMI）、24 h 平均收缩压及舒张压、24 h 平均脉压比较，差异均有统计学意义（<0.05）。（2）两组患者 TRPC1 基因多态性的分布频率比较，差异无统计学意义（>0.05）；rs7638459 基因型、等位基因及隐性模型比较，差异均有统计学意义（<0.05）。（3）Logistic 回归分析显示，BMI 和 rs7638459 CC 基因型是原发性高血压患者微量白蛋白尿增加的危险因素。结论：TRPC1 基因多态性与原发性高血压患者微量白蛋白尿有关，rs7638459 中的 CC 基因型可能会增加原发性高血压患者微量白蛋白尿的患病风险，而 BMI 和 rs7638459 CC 基因型可能是原发性高血压患者微量白蛋白尿增加的危险因素。
