Department 2 of Comprehensive Internal Medicine of Healthy Care Center for Cadres, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Department of Intensive Care Unit, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Med Sci Monit. 2024 May 21;30:e942667. doi: 10.12659/MSM.942667.
BACKGROUND Obstructive sleep apnea-hypopnea syndrome (OSAHS) presents a significant health concern, particularly among individuals with essential hypertension (EH). Understanding the genetic underpinnings of this association is crucial for effective management and intervention. We investigated the relationship between TRPC3 gene polymorphisms and susceptibility to OSAHS in patients with EH. MATERIAL AND METHODS We enrolled 373 patients with EH hospitalized at the First Affiliated Hospital of Xinjiang Medical University between April 2015 and November 2017. Patients were categorized into EH (n=74) and EH+OSAHS (n=299) groups according to the apnea-hypopnea index. Sequenom detection technology was used for TRPC3 gene single-nucleotide polymorphism genotyping, including genotypes at rs953691, rs10518289, rs2292232, rs4995894, rs951974, and rs4292355. RESULTS Sex, smoking history, alcohol history, hypertension duration, fasting blood glucose, urea, creatinine, total cholesterol, HDL-C, LDL-C, glycosylated hemoglobin, 24-h mean systolic BP, and 24-h mean diastolic BP were not significantly different between the 2 groups (P>0.05); however, age, BMI, triglyceride levels differed significantly (P<0.05). No significant difference was detected in distribution frequency of polymorphisms of TRPC3 gene between the 2 groups (P>0.05), while genotype, dominant genotype, and recessive genotype at rs10518289 and alleles at rs4292355 differed significantly (P<0.05). Logistic regression analysis showed age, BMI, and CG+GG genotypes at rs10518289 were risk factors for OSAHS in patients with EH. Interaction between TRPC3 (rs10518289) and obesity was not a risk of OSAHS with EH (P>0.05). CONCLUSIONS CC genotype of rs10518289 in the TRPC3 gene could be a protective genetic marker of OSAHS, and CG+GG genotype may be a risk genetic marker of OSAHS with EH.
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是一个严重的健康问题，尤其在原发性高血压（EH）患者中更为常见。了解这种关联的遗传基础对于有效的管理和干预至关重要。我们研究了 TRPC3 基因多态性与 EH 患者 OSAHS 易感性之间的关系。
我们纳入了 2015 年 4 月至 2017 年 11 月在新疆医科大学第一附属医院住院的 373 例 EH 患者。根据呼吸暂停低通气指数，患者分为 EH 组（n=74）和 EH+OSAHS 组（n=299）。采用Sequenom 检测技术对 TRPC3 基因单核苷酸多态性进行基因分型，包括 rs953691、rs10518289、rs2292232、rs4995894、rs951974 和 rs4292355 的基因型。
两组间性别、吸烟史、饮酒史、高血压病程、空腹血糖、尿素氮、肌酐、总胆固醇、HDL-C、LDL-C、糖化血红蛋白、24 小时平均收缩压和 24 小时平均舒张压差异均无统计学意义（P>0.05）；年龄、BMI、三酰甘油水平差异有统计学意义（P<0.05）。两组间 TRPC3 基因多态性分布频率差异无统计学意义（P>0.05），rs10518289 基因型、显性基因型、隐性基因型和 rs4292355 等位基因差异有统计学意义（P<0.05）。Logistic 回归分析显示，年龄、BMI 和 rs10518289 的 CG+GG 基因型是 EH 患者 OSAHS 的危险因素。TRPC3（rs10518289）与肥胖之间的相互作用不是 EH 合并 OSAHS 的危险因素（P>0.05）。
TRPC3 基因 rs10518289 的 CC 基因型可能是 OSAHS 的保护性遗传标志物，CG+GG 基因型可能是 EH 合并 OSAHS 的危险因素。
